Effect of Z-103 on compound 48/80-induced gastric lesions in rats

Z-103 (a novel anti-ulcer agent), given p.o. at doses of 30 and 100 mg/kg, significantly prevented gastric lesions induced by compound 48/80 in rats. Z-103 inhibited the histamine release from rat peritoneal mast cells stimulated by compound 48/80 in a dose-dependent manner. Z-103 inhibited the incr...

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Bibliographic Details
Published inScandinavian journal of gastroenterology. Supplement Vol. 162; p. 202
Main Authors Ueki, S, Seiki, M, Yoneta, T, Omata, T, Hori, Y, Ishikawa, M, Tagashira, E
Format Journal Article
LanguageEnglish
Published England 1989
Subjects
Animals
Carnosine - analogs & derivatives
Gastric Mucosa - metabolism
Histamine Release - drug effects
Histidine - analogs & derivatives
Histidine - pharmacology
Male
Mast Cells - metabolism
Organometallic Compounds - pharmacology
p-Methoxy-N-methylphenethylamine
Peritoneal Cavity - cytology
Rats
Rats, Inbred Strains
Stomach - pathology
Stomach Diseases - chemically induced
Stomach Diseases - pathology
Thiobarbiturates
Zinc Compounds
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Summary:Z-103 (a novel anti-ulcer agent), given p.o. at doses of 30 and 100 mg/kg, significantly prevented gastric lesions induced by compound 48/80 in rats. Z-103 inhibited the histamine release from rat peritoneal mast cells stimulated by compound 48/80 in a dose-dependent manner. Z-103 inhibited the increase in thiobarbituric acid (TBA) reactants induced by a single or repeated administration of compound 48/80 in the gastric mucosa. These observations suggested that the protective effect of Z-103 against compound 48/80-induced gastric lesions may be due to its stabilizing activity toward mast cells and/or an antioxidative effect on the gastric mucosa.
ISSN:0085-5928
DOI:10.3109/00365528909091161