Imprint cytology improves accuracy of computed tomography-guided percutaneous transthoracic needle biopsy

The aim of the present study was to investigate whether imprint cytology can improve the diagnostic accuracy of computed tomography-guided transthoracic core biopsy. Between October 1997 and June 2004, thoracic lesions in 622 patients underwent biopsy using 19-gauge coaxial guiding needles and 20-ga...

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Bibliographic Details
Published inThe European respiratory journal Vol. 31; no. 1; pp. 54 - 61
Main Authors Chang, Y-C, Yu, C-J, Lee, W-J, Kuo, S-H, Hsiao, C-H, Jan, I-S, Hu, F-C, Liu, H-M, Chan, W-K, Yang, P-C
Format Journal Article
LanguageEnglish
Published Leeds Eur Respiratory Soc 01.01.2008
Maney
Subjects
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biopsy
Biopsy, Needle
Cytological Techniques
Female
Humans
Lung Diseases - diagnosis
Lung Diseases - pathology
Male
Medical sciences
Middle Aged
Pneumology
Reproducibility of Results
Solitary Pulmonary Nodule - diagnosis
Solitary Pulmonary Nodule - pathology
Tomography, X-Ray Computed - methods
diagnostic accuracy
needle lung biopsy
Radiodiagnosis
Lung
Cytology
Percutaneous route
Guidance
Accuracy
Computed tomography
Biopsy
Needle
Medical imagery
Computerized axial tomography
Diagnosis
Pneumology
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Summary:The aim of the present study was to investigate whether imprint cytology can improve the diagnostic accuracy of computed tomography-guided transthoracic core biopsy. Between October 1997 and June 2004, thoracic lesions in 622 patients underwent biopsy using 19-gauge coaxial guiding needles and 20-gauge biopsy needles under computed tomography guidance. Touch imprint cytology and histopathology were performed for all biopsy specimens. Of these lesions, 431 (74.1%) were diagnosed as malignant, 151 (25.9%) as benign and 40 (6%) as nondiagnostic. Imprint cytology plus histology shows an improved diagnostic accuracy of 96.4% compared with that of imprint cytology alone (92.3%) or histopathology alone (93.0%). Procedure-related complications requiring further treatment occurred in eight (1.4%) patients. In conclusion, imprint cytology combined with histopathology can improve the diagnostic accuracy of computed tomography-guided transthoracic needle biopsy.
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ISSN:0903-1936
1399-3003
DOI:10.1183/09031936.00038907