A new cytotoxic iridoid from Callicarpa nudiflora

A new iridoid, named nudifloside (1), together with three known compounds, was isolated from the EtOH extract of the aerial parts of Callicarpa nudiflora Hook. The structures were elucidated by a study of their physical and spectral data. Nudifloside (1) and the isolated known compound linearoside (...

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Published inNatural product research Vol. 24; no. 10; pp. 899 - 904
Main Authors Mei, Wen-Li, Han, Zhuang, Cui, Hai-Bin, Zhao, You-Xing, Deng, Yuan-Yuan, Dai, Hao-Fu
Format Journal Article
LanguageEnglish
Published England Taylor & Francis Group 01.06.2010
Subjects
Callicarpa - chemistry
Callicarpa nudiflora
Cell Line, Tumor
Cell Proliferation - drug effects
cytotoxicity
Humans
Inhibitory Concentration 50
iridoid
Iridoids - chemistry
Iridoids - pharmacology
Magnetic Resonance Spectroscopy
Molecular Structure
nudifloside
Plant Components, Aerial - chemistry
Plant Extracts - chemistry
Plant Extracts - pharmacology
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Summary:A new iridoid, named nudifloside (1), together with three known compounds, was isolated from the EtOH extract of the aerial parts of Callicarpa nudiflora Hook. The structures were elucidated by a study of their physical and spectral data. Nudifloside (1) and the isolated known compound linearoside (2) displayed inhibitory effects towards chronic myelogenous leukaemia K562 cell line, with IC 50 values of 20.7 and 36.0 µg mL −1 , respectively.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1478-6419
1478-6427
DOI:10.1080/14786410802267544