Anaphylaxis: An Uncommon Cause of Rhabdomyolysis-Related Acute Kidney Injury

Anaphylaxis is an acute, severe, and potentially lethal form of an allergic reaction. It can lead to a sepsis-like syndrome and multisystem involvement with complications. It can cause distributive shock with preferential blood supply to vital organs, at the expense of blood supply to skeletal muscl...

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Bibliographic Details
Published inSaudi journal of kidney diseases and transplantation Vol. 32; no. 6; pp. 1826 - 1829
Main Authors Shankar, G., Mahapatra, Debasish, Jha, Vijoy
Format Journal Article
LanguageEnglish
Published Riyadh Wolters Kluwer India Pvt. Ltd 01.11.2021
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Wolters Kluwer Medknow Publications
Subjects
Anaphylaxis
Muscles
Rhabdomyolysis
Shock
Succinylcholine
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Summary:Anaphylaxis is an acute, severe, and potentially lethal form of an allergic reaction. It can lead to a sepsis-like syndrome and multisystem involvement with complications. It can cause distributive shock with preferential blood supply to vital organs, at the expense of blood supply to skeletal muscle. Skeletal muscle ischemia leads to the fast depletion of myocyte energy source and a cascade of inflammatory reactions leading to myocyte injury and death. Myocyte lysis or rhabdomyolysis releases the cellular contents into circulation. Rhabdomyolysis is not an oft-discussed complication of anaphylaxis. We describe a 21-year-old male with no known comorbidity who presented with anaphylactic shock after consuming one tablet paracetamol + ibuprofen and was found to have rhabdomyolysis-related acute kidney injury.
ISSN:1319-2442
2320-3838
DOI:10.4103/1319-2442.352449