Bone repair and augmentation using block of sintered bovine-derived anorganic bone graft in cranial bone defect model
Objective: To histomorphometrically investigate the repair of critical size defects (CSDs) and bone augmentation in cranial walls using block of sintered bovine‐derived anorganic bone (sBDAB) graft. Material and methods: Forty guinea‐pigs were divided into test (n=20) and CSD control (n=20) groups....
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Published in | Clinical oral implants research Vol. 20; no. 4; pp. 340 - 350 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.04.2009
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Subjects | |
Online Access | Get full text |
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Summary: | Objective: To histomorphometrically investigate the repair of critical size defects (CSDs) and bone augmentation in cranial walls using block of sintered bovine‐derived anorganic bone (sBDAB) graft.
Material and methods: Forty guinea‐pigs were divided into test (n=20) and CSD control (n=20) groups. In each animal, a full‐thickness bone defect with 9.5 mm diameter was made in the frontal bone. The defects were filled with an sBDAB block soaked in blood in the test group and with blood clot in the CSD control group. The skulls were collected at 0 h (n=2) and 30, 90 and 180 days (n=6/group and period) postoperatively. The volume density and total volume of newly formed bone, sBDAB, blood vessels and connective tissue, vertical thickness of removed bone plug, sBDAB block and graft area were evaluated.
Results: The vertical thickness of the adapted sBDAB block was 3.8 times higher than that of the removed bone plug and did not show significant difference between periods, filling in average 29.8% of the total graft region. The sBDAB block exhibited complete osseointegration with the borders of the defect at 90 days. At 90 and 180 days, the vertical thickness of the graft was 279% in the average, and the total volume of bone augmentation was, respectively, 78.8% and 148.5% higher compared with the removed bone plug. The defects of the CDS control group showed limited osteogenesis and filling by connective tissue plus tegument.
Conclusion: The sBDAB block can be used to promote repair of CSDs and bone augmentation in the craniomaxillofacial region, due to its good osteoconductive and slow resorptive properties. |
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Bibliography: | ArticleID:CLR1659 ark:/67375/WNG-V60G12S9-3 istex:52ABABA1D97D7E9670E6B52892A3C7F79087F5AD ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
ISSN: | 0905-7161 1600-0501 |
DOI: | 10.1111/j.1600-0501.2008.01659.x |