Association between IL-1A single nucleotide polymorphisms and chronic beryllium disease and beryllium sensitization

• Published in: Journal of occupational and environmental medicine Vol. 52; no. 7; p. 680
• Main Authors: McCanlies, Erin C, Yucesoy, Berran, Mnatsakanova, Anna, Slaven, James E, Andrew, Michael, Frye, Bonnie L, Schuler, Christine R, Kreiss, Kathleen, Weston, Ainsley
• Format: Journal Article
• Language: English
• Published: United States 01.07.2010
• Subjects: Berylliosis - genetics; Berylliosis - immunology; Beryllium - immunology; Chronic Disease; Cohort Studies; Genetic Association Studies; HLA-DP Antigens - genetics; HLA-DP Antigens - immunology; HLA-DP beta-Chains; Humans; Interleukin-1 - genetics; Interleukin-1 - immunology; Interleukin-2 - genetics; Interleukin-2 - immunology; Interleukin-9 - genetics; Interleukin-9 - immunology; Polymorphism, Single Nucleotide; Receptors, Interleukin-9 - genetics; Receptors, Interleukin-9 - immunology; Respiratory Hypersensitivity - genetics; Respiratory Hypersensitivity - immunology
• ISSN: 1536-5948
• DOI: 10.1097/JOM.0b013e3181e48ec8

To determine if single nucleotide polymorphisms (SNPs) in interleukin (IL) IL-1A, IL-1B, IL-1RN, IL-2, IL-9, and IL-9R were associated with chronic beryllium disease (CBD) and beryllium sensitization (BeS). Forty SNPs in six IL genes were evaluated in 85 individuals with CBD, 61 individuals with BeS, and 730 individuals without BeS or CBD (nonsensitized) using a 5' nuclease polymerase chain reaction assay. Logistic regression was used to evaluate the association between IL SNPs, CBD, and BeS, adjusting for plant-site and HLA-DPB1Glu69 in additive, dominant, and recessive inheritance models. IL-1A-1142, IL-1A-3769, and IL-1A-4697 were significantly associated with CBD in both the additive and dominant models compared to individuals with BeS or the nonsensitized. These results indicate that genetic variations in the IL-1A gene may play a role in the development of CBD but not BeS.