Quantitative deviating effects of maple syrup extract supplementation on the hepatic gene expression of mice fed a high‐fat diet

Scope Maple syrup contains various polyphenols and we investigated the effects of a polyphenol‐rich maple syrup extract (MSXH) on the physiology of mice fed a high‐fat diet (HFD). Methods and results The mice fed a low‐fat diet (LFD), an HFD, or an HFD supplemented with 0.02% (002MSXH) or 0.05% MSXH...

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Published inMolecular nutrition & food research Vol. 61; no. 2; pp. np - n/a
Main Authors Kamei, Asuka, Watanabe, Yuki, Shinozaki, Fumika, Yasuoka, Akihito, Shimada, Kousuke, Kondo, Kaori, Ishijima, Tomoko, Toyoda, Tsudoi, Arai, Soichi, Kondo, Takashi, Abe, Keiko
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 01.02.2017
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Summary:Scope Maple syrup contains various polyphenols and we investigated the effects of a polyphenol‐rich maple syrup extract (MSXH) on the physiology of mice fed a high‐fat diet (HFD). Methods and results The mice fed a low‐fat diet (LFD), an HFD, or an HFD supplemented with 0.02% (002MSXH) or 0.05% MSXH (005MSXH) for 4 weeks. Global gene expression analysis of the liver was performed, and the differentially expressed genes were classified into three expression patterns; pattern A (LFD < HFD > 002MSXH = 005MSXH, LFD > HFD < 002MSXH = 005MSXH), pattern B (LFD < HFD = 002MSXH > 005MSXH, LFD > HFD = 002MSXH < 005MSXH), and pattern C (LFD < HFD > 002MSXH < 005MSXH, LFD > HFD < 002MSXH > 005MSXH). Pattern A was enriched in glycolysis, fatty acid metabolism, and folate metabolism. Pattern B was enriched in tricarboxylic acid cycle while pattern C was enriched in gluconeogenesis, cholesterol metabolism, amino acid metabolism, and endoplasmic reticulum stress‐related event. Conclusion Our study suggested that the effects of MSXH ingestion showed (i) dose‐dependent pattern involved in energy metabolisms and (ii) reversely pattern involved in stress responses. Ingestion of a polyphenol‐rich maple syrup extract (MSXH, containing 15.02% w/w polyphenols) has effects on the hepatic gene expression of mice fed a high‐fat diet. Global gene expression analysis of the liver is performed, and the differentially expressed genes are classified into three expression patterns. Patterns A and B in this figure involve genes working in energy metabolisms and pattern C involves genes in stress responses.
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ISSN:1613-4125
1613-4133
DOI:10.1002/mnfr.201600477