Human nocturnal blood melatonin and liver acetylation status

The human dark phase melatonin concentrations exhibit a wide range of values. In an attempt to explain this variation, we measured 2250-2305 h melatonin levels by radioimmune assay in eleven fast and eleven slow acetylator phenotypes. No statistical difference between the two groups existed, suggest...

Full description

Saved in:
Bibliographic Details
Published inJournal of pineal research Vol. 10; no. 1; p. 14
Main Authors Smith, J A, Helliwell, P S, Isdale, A, Astbury, C, Padwick, D J, Bird, H A
Format Journal Article
LanguageEnglish
Published England 01.01.1991
Subjects
Acetylation
Adolescent
Adult
Arylamine N-Acetyltransferase - genetics
Arylamine N-Acetyltransferase - metabolism
Body Constitution
Body Weight
Darkness
Female
Humans
Liver - enzymology
Male
Melatonin - blood
Middle Aged
Polymorphism, Genetic
Radioimmunoassay
Random Allocation
Online AccessGet more information

Cover

More Information
Summary:The human dark phase melatonin concentrations exhibit a wide range of values. In an attempt to explain this variation, we measured 2250-2305 h melatonin levels by radioimmune assay in eleven fast and eleven slow acetylator phenotypes. No statistical difference between the two groups existed, suggesting therefore that such variations are not due to acetylator status. The study revealed a negative relationship between body weight or area and nocturnal melatonin concentration. No correlation was found between dark phase melatonin levels and age, anxiety, depression, or sleep rating.
ISSN:0742-3098
DOI:10.1111/j.1600-079X.1991.tb00004.x