Vitamin D deficiency is associated with inferior survival of patients with extranodal natural killer/T‐cell lymphoma

• Published in: Cancer science Vol. 109; no. 12; pp. 3971 - 3980
• Main Authors: Kim, Seok Jin, Shu, Cheng, Ryu, Kyung Ju, Kang, Danbee, Cho, Juhee, Ko, Young Hyeh, Lee, Soo‐Youn, Guallar, Eliseo, Zhao, Weili, Kim, Won Seog
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.12.2018; John Wiley and Sons Inc
• Subjects: 25-Hydroxyvitamin D; Adolescent; Adult; Aged; Aged, 80 and over; Cell survival; Chemotherapy; Chromatography; Cytokines; Cytokines - blood; Female; Gene expression; Hospitals; Hospitals, University; Humans; Inflammation; Laboratories; Lymphoma; Lymphoma, Extranodal NK-T-Cell - blood; Lymphoma, Extranodal NK-T-Cell - metabolism; Lymphoma, Extranodal NK-T-Cell - mortality; Lymphoma, T-Cell, Peripheral - blood; Lymphoma, T-Cell, Peripheral - metabolism; Lymphoma, T-Cell, Peripheral - mortality; Male; Medical prognosis; Middle Aged; Natural killer cells; NK/T‐cell lymphoma; Original; Pathology; Population; prognosis; Prospective Studies; Studies; survival; Survival Analysis; T-cell lymphoma; Vitamin D; Vitamin D - blood; Vitamin D Deficiency - blood; Vitamin D Deficiency - diagnosis; Vitamin deficiency; Young Adult; Ann Arbor Michigan; United States > US; NK/T-cell lymphoma; chemotherapy; prognosis; vitamin D; survival
• ISSN: 1347-9032; 1349-7006
• DOI: 10.1111/cas.13844

Vitamin D deficiency is a common health issue; however, the effect of vitamin D deficiency on the survival of T‐cell lymphoma is still not clear. We evaluated the impact of serum vitamin D level of patients with peripheral T‐cell lymphoma (PTCL) and extranodal natural killer/T‐cell lymphoma (ENKTL) on survival outcome. Pretreatment levels of 25‐hydroxyvitamin D [25(OH)D] and inflammatory cytokines were measured in serum samples that were archived at diagnosis, and we evaluated their association with survival in newly diagnosed patients with PTCL (n = 137) and ENKTL (n = 114) at a university‐based hospital in Korea. An independent cohort from Rui Jin Hospital (Shanghai, China) was used for validation. The median 25(OH)D serum level was 12.0 ng/mL (1.3‐60.0 ng/mL), and 40% had less than 10 ng/mL, which was defined as vitamin D deficiency. Median serum 25(OH)D levels were similar between PTCL (11.5 ng/mL) and ENKTL (12.9 ng/mL); however, vitamin D deficiency was associated with inferior survival in ENKTL but not with PTCL. The independent validation cohort (n = 115) also showed a significant association of vitamin D deficiency with poor survival in ENKTL. The 25(OH)D level had an inverse relation with inflammatory cytokines; this association had a negative effect only on survival of ENKTL, and not on PTCL. In conclusion, vitamin D deficiency was associated with inferior survival outcome of patients with ENKTL. Vitamin D deficiency was associated with inferior survival of extranodal NK/T‐cell lymphoma but not with peripheral T‐cell lymphoma. Poor prognosis of vitamin D deficiency was related with increased inflammatory cytokines in extranodal NK/T‐cell lymphoma.