Trends in big data analyses by multicenter collaborative translational research in psychiatry

• Published in: Psychiatry and clinical neurosciences Vol. 76; no. 1; pp. 1 - 14
• Main Authors: Onitsuka, Toshiaki, Hirano, Yoji, Nemoto, Kiyotaka, Hashimoto, Naoki, Kushima, Itaru, Koshiyama, Daisuke, Koeda, Michihiko, Takahashi, Tsutomu, Noda, Yoshihiro, Matsumoto, Junya, Miura, Kenichiro, Nakazawa, Takanobu, Hikida, Takatoshi, Kasai, Kiyoto, Ozaki, Norio, Hashimoto, Ryota
• Format: Journal Article
• Language: English
• Published: Melbourne John Wiley & Sons Australia, Ltd 01.01.2022; Wiley Subscription Services, Inc
• Subjects: Animals; autism spectrum disorder; Big Data; bipolar disorder; COCORO; Cognition; Cognitive ability; Collaboration; Data Analysis; Humans; major depressive disorder; Medical imaging; Mental disorders; Mental Disorders - genetics; Meta-analysis; Meta-Analysis as Topic; Multicenter Studies as Topic; Nervous system; Neuroimaging; Neurosciences; PCN Frontier Review; Psychiatry; Reproducibility of Results; Reviews; schizophrenia; Translational Research, Biomedical; COCORO; bipolar disorder; schizophrenia; major depressive disorder; autism spectrum disorder
• ISSN: 1323-1316; 1440-1819
• DOI: 10.1111/pcn.13311

The underlying pathologies of psychiatric disorders, which cause substantial personal and social losses, remain unknown, and their elucidation is an urgent issue. To clarify the core pathological mechanisms underlying psychiatric disorders, in addition to laboratory‐based research that incorporates the latest findings, it is necessary to conduct large‐sample‐size research and verify reproducibility. For this purpose, it is critical to conduct multicenter collaborative research across various fields, such as psychiatry, neuroscience, molecular biology, genomics, neuroimaging, cognitive science, neurophysiology, psychology, and pharmacology. Moreover, collaborative research plays an important role in the development of young researchers. In this respect, the Enhancing Neuroimaging Genetics through Meta‐Analysis (ENIGMA) consortium and Cognitive Genetics Collaborative Research Organization (COCORO) have played important roles. In this review, we first overview the importance of multicenter collaborative research and our target psychiatric disorders. Then, we introduce research findings on the pathophysiology of psychiatric disorders from neurocognitive, neurophysiological, neuroimaging, genetic, and basic neuroscience perspectives, focusing mainly on the findings obtained by COCORO. It is our hope that multicenter collaborative research will contribute to the elucidation of the pathological basis of psychiatric disorders.