KLF2 Mediates the Suppressive Effect of Laminar Flow on Vascular Calcification by Inhibiting Endothelial BMP/SMAD1/5 Signaling

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Bibliographic Details
Published inCirculation research Vol. 129; no. 4; pp. e87 - e100
Main Authors Huang, Juan, Pu, Yujie, Zhang, Hongsong, Xie, Liping, He, Lei, Zhang, Cheng-Lin, Cheng, Chak Kwong, Huo, Yingsong, Wan, Song, Chen, Shaoliang, Huang, Yuhong, Lau, Chi Wai, Wang, Li, Xia, Yin, Huang, Yu, Luo, Jiang-Yun
Format Journal Article
LanguageEnglish
Published United States Lippincott Williams & Wilkins 06.08.2021
Subjects
Aged
Aged, 80 and over
Animals
Aorta - metabolism
Aorta - pathology
Blood Circulation
Bone Morphogenetic Proteins - metabolism
Endothelium, Vascular - metabolism
Endothelium, Vascular - pathology
Epithelial-Mesenchymal Transition
Female
HEK293 Cells
Human Umbilical Vein Endothelial Cells - metabolism
Humans
Kruppel-Like Transcription Factors - genetics
Kruppel-Like Transcription Factors - metabolism
Male
Mice
Mice, Inbred C57BL
Middle Aged
Signal Transduction
Smad Proteins - metabolism
Vascular Calcification - metabolism
Vascular Calcification - physiopathology
endothelial cells
vascular calcification
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Summary:[Figure: see text].
Bibliography:ObjectType-Article-1
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ISSN:0009-7330
1524-4571
1524-4571
DOI:10.1161/CIRCRESAHA.120.318690