Metagenomic analysis reveals that bacteriophages are reservoirs of antibiotic resistance genes

Highlights • We explored the presence of antibiotic resistance genes (ARGs) in phage and bacterial DNA fractions from hospital wastewater. • The relative abundance of ARGs was higher in the phage DNA fraction than in the bacterial DNA fraction. • Novel variants of β-lactamases were identified both i...

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Bibliographic Details
Published inInternational journal of antimicrobial agents Vol. 48; no. 2; pp. 163 - 167
Main Authors Subirats, Jéssica, Sànchez-Melsió, Alexandre, Borrego, Carles M, Balcázar, José Luis, Simonet, Pascal
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.08.2016
Elsevier
Subjects
Antibiotic resistance genes
Bacteria - drug effects
Bacteria - virology
Bacteriophages
Bacteriophages - classification
Bacteriophages - genetics
Bacteriophages - isolation & purification
Caudovirales - classification
Caudovirales - genetics
Caudovirales - isolation & purification
Drug Resistance, Bacterial
Electric power
Engineering Sciences
Gene Transfer, Horizontal
Genes, Bacterial
Genes, Viral
Horizontal gene transfer
Hospitals
Infectious Disease
Metagenomics
Waste Water - virology
Bacteriophages
Antibiotic resistance genes
Horizontal gene transfer
resistance genes
Antibiotic
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Summary:Highlights • We explored the presence of antibiotic resistance genes (ARGs) in phage and bacterial DNA fractions from hospital wastewater. • The relative abundance of ARGs was higher in the phage DNA fraction than in the bacterial DNA fraction. • Novel variants of β-lactamases were identified both in phage and bacterial DNA fractions. • Phages represent a potential reservoir of ARGs.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2016.04.028