A pathophysiology-based approach to the diagnosis and treatment of lupus nephritis

Lupus is no longer an unknown chameleon of medicine. Significant progress has been made on unraveling the pathogenesis of lupus and lupus nephritis, and how to treat the disease. Here we provide an update on the pathophysiology of lupus and its related kidney disease, consider areas of controversy i...

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Bibliographic Details
Published inKidney international Vol. 90; no. 3; pp. 493 - 501
Main Authors Anders, Hans-Joachim, Rovin, Brad
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.09.2016
Subjects
Antibodies, Antinuclear - immunology
Autoimmunity
Biomarkers - analysis
Biopsy
Clinical Trials as Topic
disease activity
Genetic Predisposition to Disease
Glucocorticoids - administration & dosage
Glucocorticoids - therapeutic use
Humans
immune complex
Immunosuppressive Agents - administration & dosage
Immunosuppressive Agents - therapeutic use
Kidney - immunology
Kidney - pathology
Lupus Nephritis - drug therapy
Lupus Nephritis - genetics
Lupus Nephritis - immunology
Lupus Nephritis - pathology
Membrane Proteins - genetics
Mutation
proteinuria
Proteinuria - urine
trial design
disease activity
autoimmunity
trial design
immune complex
proteinuria
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Summary:Lupus is no longer an unknown chameleon of medicine. Significant progress has been made on unraveling the pathogenesis of lupus and lupus nephritis, and how to treat the disease. Here we provide an update on the pathophysiology of lupus and its related kidney disease, consider areas of controversy in disease management, and discuss the unmet needs of lupus nephritis and how to address these needs. We focus on rethinking how innovative therapies for lupus nephritis should be evaluated and evolving strategies to more efficiently mitigate irreversible nephron loss in patients with lupus nephritis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0085-2538
1523-1755
DOI:10.1016/j.kint.2016.05.017