Dual-responsive nanoparticles release cargo upon exposure to matrix metalloproteinase and reactive oxygen species

Micellar nanoparticles were designed to be responsive to matrix metalloproteinases (MMPs) and reactive oxygen species (ROS), each of which is upregulated in the pathology of inflammatory diseases. The amphiphilic polymer-based nanoparticle system consists of a hydrophilic shell responsible for parti...

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Published inChemical communications (Cambridge, England) Vol. 52; no. 1; pp. 2126 - 2128
Main Authors Daniel, Kevin B, Callmann, Cassandra E, Gianneschi, Nathan C, Cohen, Seth M
Format Journal Article
LanguageEnglish
Published England 01.01.2016
Subjects
Agglomeration
Blocking
Cargo
chemical compounds
chemical reactions
Diseases
Exposure
hydrophilicity
Hydrophobic and Hydrophilic Interactions
hydrophobicity
Matrix metalloproteinases
Matrix Metalloproteinases - chemistry
Matrix Metalloproteinases - metabolism
metalloproteinases
Nanoparticles
Nanoparticles - chemistry
Pathology
Polymers - chemistry
reactive oxygen species
Reactive Oxygen Species - chemistry
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Abstract Micellar nanoparticles were designed to be responsive to matrix metalloproteinases (MMPs) and reactive oxygen species (ROS), each of which is upregulated in the pathology of inflammatory diseases. The amphiphilic polymer-based nanoparticle system consists of a hydrophilic shell responsible for particle morphology change and aggregation, together with a hydrophobic block designed to release cargo in the presence of ROS. Micellar nanoparticles were designed to be responsive to matrix metalloproteinases (MMPs) and reactive oxygen species (ROS), each of which is upregulated in the pathology of inflammatory diseases.
AbstractList Micellar nanoparticles were designed to be responsive to matrix metalloproteinases (MMPs) and reactive oxygen species (ROS), each of which is upregulated in the pathology of inflammatory diseases. The amphiphilic polymer-based nanoparticle system consists of a hydrophilic shell responsible for particle morphology change and aggregation, together with a hydrophobic block designed to release cargo in the presence of ROS.
Micellar nanoparticles were designed to be responsive to matrix metalloproteinases (MMPs) and reactive oxygen species (ROS), each of which is upregulated in the pathology of inflammatory diseases. The amphiphilic polymer-based nanoparticle system consists of a hydrophilic shell responsible for particle morphology change and aggregation, together with a hydrophobic block designed to release cargo in the presence of ROS. Micellar nanoparticles were designed to be responsive to matrix metalloproteinases (MMPs) and reactive oxygen species (ROS), each of which is upregulated in the pathology of inflammatory diseases.
Author Gianneschi, Nathan C
Cohen, Seth M
Callmann, Cassandra E
Daniel, Kevin B
AuthorAffiliation Department of Chemistry and Biochemistry
University of California
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  givenname: Nathan C
  surname: Gianneschi
  fullname: Gianneschi, Nathan C
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  givenname: Seth M
  surname: Cohen
  fullname: Cohen, Seth M
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26696280$$D View this record in MEDLINE/PubMed
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Snippet Micellar nanoparticles were designed to be responsive to matrix metalloproteinases (MMPs) and reactive oxygen species (ROS), each of which is upregulated in...
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SubjectTerms Agglomeration
Blocking
Cargo
chemical compounds
chemical reactions
Diseases
Exposure
hydrophilicity
Hydrophobic and Hydrophilic Interactions
hydrophobicity
Matrix metalloproteinases
Matrix Metalloproteinases - chemistry
Matrix Metalloproteinases - metabolism
metalloproteinases
Nanoparticles
Nanoparticles - chemistry
Pathology
Polymers - chemistry
reactive oxygen species
Reactive Oxygen Species - chemistry
Title Dual-responsive nanoparticles release cargo upon exposure to matrix metalloproteinase and reactive oxygen species
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