Dual-responsive nanoparticles release cargo upon exposure to matrix metalloproteinase and reactive oxygen species

Micellar nanoparticles were designed to be responsive to matrix metalloproteinases (MMPs) and reactive oxygen species (ROS), each of which is upregulated in the pathology of inflammatory diseases. The amphiphilic polymer-based nanoparticle system consists of a hydrophilic shell responsible for parti...

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Published inChemical communications (Cambridge, England) Vol. 52; no. 1; pp. 2126 - 2128
Main Authors Daniel, Kevin B, Callmann, Cassandra E, Gianneschi, Nathan C, Cohen, Seth M
Format Journal Article
LanguageEnglish
Published England 01.01.2016
Subjects
Agglomeration
Blocking
Cargo
chemical compounds
chemical reactions
Diseases
Exposure
hydrophilicity
Hydrophobic and Hydrophilic Interactions
hydrophobicity
Matrix metalloproteinases
Matrix Metalloproteinases - chemistry
Matrix Metalloproteinases - metabolism
metalloproteinases
Nanoparticles
Nanoparticles - chemistry
Pathology
Polymers - chemistry
reactive oxygen species
Reactive Oxygen Species - chemistry
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Summary:Micellar nanoparticles were designed to be responsive to matrix metalloproteinases (MMPs) and reactive oxygen species (ROS), each of which is upregulated in the pathology of inflammatory diseases. The amphiphilic polymer-based nanoparticle system consists of a hydrophilic shell responsible for particle morphology change and aggregation, together with a hydrophobic block designed to release cargo in the presence of ROS. Micellar nanoparticles were designed to be responsive to matrix metalloproteinases (MMPs) and reactive oxygen species (ROS), each of which is upregulated in the pathology of inflammatory diseases.
Bibliography:10.1039/c5cc09164k
Electronic supplementary information (ESI) available: Synthetic schemes, NMR data, and experimental details. See DOI
ObjectType-Article-1
SourceType-Scholarly Journals-1
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These authors contributed equally.
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/c5cc09164k