Genomic Analysis and Geographic Visualization of the Spread of Avian Influenza (H5N1)

• Published in: Systematic biology Vol. 56; no. 2; pp. 321 - 329
• Main Authors: Janies, Daniel, Hill, Andrew W., Guralnick, Robert, Habib, Farhat, Waltari, Eric, Wheeler, Ward C., Page, Rod
• Format: Journal Article
• Language: English
• Published: England Society of Systematic Zoology 01.04.2007; Taylor & Francis; Oxford University Press
• Subjects: Animals; Birds; Complex systems; Datasets; Drug Resistance, Viral; Evolution, Molecular; Genome, Viral; Genomes; Genomics; Genotype; Genotype & phenotype; Genotypes; Geography; H5N1 subtype influenza A virus; Infections; Influenza A virus; Influenza A Virus, H5N1 Subtype - genetics; Influenza in Birds - genetics; Influenza in Birds - transmission; Influenza in Birds - virology; Models, Biological; Mutation; Phylogenetics; Points of View; Proteins; Public health; Taxa; Time Factors; Viruses; Wildlife conservation
• ISSN: 1063-5157; 1076-836X
• DOI: 10.1080/10635150701266848

Pandemic influenza would have severe implications for public health, economic security, food safety, and wildlife conservation.\n These genotypes in surface proteins do not correlate statistically or visually to host use by H5N1 as determined by our character mapping approaches, despite the experimentally indicated roles in mediating the efficacy and specificity of viral surface proteins with receptors on various host cells (Stevens, 2006; Chen, 2006). Genomic sequencing of key Avian Influenza isolates was funded by the National Institutes of Health, National Institute of Allergic and Infectious diseases, and performed at the Institute for Genomic Research.