Stupor and Fast Activity on Electroencephalography in a Child Treated With Valproate
The case of a 4-year-old girl with valproate-induced stupor and electroencephalographic pattern of increased fast activity is reported. Stupor and fast activity have been related to the effects on γ-aminobutyric acid type A (GABAA ) receptors mediated by endozepines or by exogenous drugs such as ben...
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Published in | Pediatric neurology Vol. 41; no. 1; pp. 53 - 56 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
New York, NY
Elsevier Inc
01.07.2009
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | The case of a 4-year-old girl with valproate-induced stupor and electroencephalographic pattern of increased fast activity is reported. Stupor and fast activity have been related to the effects on γ-aminobutyric acid type A (GABAA ) receptors mediated by endozepines or by exogenous drugs such as benzodiazepines or barbiturates. The action of valproate in GABA metabolism and in GABA neuronal networks could produce a similar result through a hyperrecruitment of GABA-mediated postsynaptic transmission. |
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ISSN: | 0887-8994 1873-5150 |
DOI: | 10.1016/j.pediatrneurol.2009.02.003 |