Stupor and Fast Activity on Electroencephalography in a Child Treated With Valproate

The case of a 4-year-old girl with valproate-induced stupor and electroencephalographic pattern of increased fast activity is reported. Stupor and fast activity have been related to the effects on γ-aminobutyric acid type A (GABAA ) receptors mediated by endozepines or by exogenous drugs such as ben...

Full description

Saved in:
Bibliographic Details
Published inPediatric neurology Vol. 41; no. 1; pp. 53 - 56
Main Authors Mastrangelo, Mario, MD, Mariani, Rosanna, MD, Spalice, Alberto, MD, PhD, Rocchi, Valerio, Iannetti, Paola, MD
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.07.2009
Elsevier
Subjects
Biological and medical sciences
Brain - drug effects
Brain - physiopathology
Child, Preschool
Electroencephalography
Epilepsy - drug therapy
Epilepsy - physiopathology
Female
GABA Agents - adverse effects
GABA Agents - therapeutic use
Humans
Medical sciences
Nervous system (semeiology, syndromes)
Nervous system as a whole
Neurology
Pediatrics
Stupor - chemically induced
Valproic Acid - adverse effects
Valproic Acid - therapeutic use
Human
Nervous system diseases
Treatment
Electrophysiology
Electroencephalography
Valproic acid
Child
Online AccessGet full text

Cover

More Information
Summary:The case of a 4-year-old girl with valproate-induced stupor and electroencephalographic pattern of increased fast activity is reported. Stupor and fast activity have been related to the effects on γ-aminobutyric acid type A (GABAA ) receptors mediated by endozepines or by exogenous drugs such as benzodiazepines or barbiturates. The action of valproate in GABA metabolism and in GABA neuronal networks could produce a similar result through a hyperrecruitment of GABA-mediated postsynaptic transmission.
ISSN:0887-8994
1873-5150
DOI:10.1016/j.pediatrneurol.2009.02.003