Genetic Association of NPY Gene Polymorphisms with Dampness-Phlegm Pattern in Korean Stroke Patients

• Published in: Evidence-based complementary and alternative medicine Vol. 2012; no. 2012; pp. 1 - 7
• Main Authors: Lee, Myeong Soo, Lim, Ji Hye, Kang, Byoung-Kab, Ko, Mi Mi, Cha, Min Ho
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2012; Hindawi Limited
• Subjects: Alzheimer's disease; Blood pressure; Cardiovascular disease; Cerebral infarction; Chinese medicine; Cholesterol; Deoxyribonucleic acid; Diabetes; Diabetic retinopathy; DNA; Genetic testing; Genotyping; Geriatrics; Hospitals; Metabolism; Neuropeptide Y; Neuropeptides; NMR; Nuclear magnetic resonance; Obesity; Older people; Patients; Schizophrenia; Single-nucleotide polymorphism; Statistical analysis; Stroke; United States > US
• ISSN: 1741-427X; 1741-4288; 1741-4288
• DOI: 10.1155/2012/109796

Neuropeptide Y (NPY), which is widely expressed in both the central and peripheral nervous systems, has an important role in a variety of biological fields. In this study, we analyzed the distribution of NPY polymorphisms in dampness-phlegm pattern and non-dampness-phlegm pattern in elderly Korean subjects with cerebral infarction (CI). A total of 1.097 subjects (498 normal subjects and 599 CI patients, including 198 with dampness-phlegm pattern and 401 with non-dampness-phlegm pattern) participated in this study. Genotyping for five SNPs (G-1484A, C-1471T, C-399T, A1201G, and C5325T) was conducted by primer extension. The results were statistically analyzed for genetic association of NPY-polymorphisms with normal versus dampness-phlegm pattern or non-dampness-phlegm pattern subjects. Among the five SNPs tested, the T allele of C-399T has a negative association with the dampness-phlegm pattern and is marked by a decrease in serum cholesterol levels. Furthermore, serum cholesterol levels were significantly higher in dampness-phlegm pattern patients than in non-dampness-phlegm pattern patients.In this study, for the first time, the association of NPY polymorphisms with pattern identification (PI) of traditional Korean medicine (TKM) was analyzed in a large CI patient population.