Circadian rhythm in plasma concentrations of gamma-hydroxybutyric acid in alcoholics

Gamma-hydroxybutyric acid (GHB) was orally administered to six alcoholics at 09.00 and 23.00 h. The plasma concentrations of GHB show a clear circadian pattern, the area under the curve in the daytime experiments being 61% of that in the night experiments. The significance of alcohol dehydrogenase,...

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Bibliographic Details
Published inInternational journal of the addictions Vol. 16; no. 6; p. 1071
Main Authors Hoes, M J, Vree, T B, Guelen, P J
Format Journal Article
LanguageEnglish
Published United States 01.01.1981
Subjects
Adult
Alcoholism - blood
Circadian Rhythm
Humans
Hydroxybutyrates - blood
Male
Middle Aged
Sodium Oxybate
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Summary:Gamma-hydroxybutyric acid (GHB) was orally administered to six alcoholics at 09.00 and 23.00 h. The plasma concentrations of GHB show a clear circadian pattern, the area under the curve in the daytime experiments being 61% of that in the night experiments. The significance of alcohol dehydrogenase, the catabolic enzyme of GHB, for the difference is discussed. It is concluded that, although the activity of alcohol dehydrogenase in alcoholics is quantitatively disturbed, it remains subject to physiologic circadian activation.
ISSN:0020-773X
DOI:10.3109/10826088109038913