Modulation of C-reactive protein and plasma omega-6 fatty acid levels by phospholipase A2 gene polymorphisms following a 6-week supplementation with fish oil

• Published in: Prostaglandins, leukotrienes and essential fatty acids Vol. 102-103; pp. 37 - 45
• Main Authors: Tremblay, B.L., Rudkowska, I., Couture, P., Lemieux, S., Julien, P., Vohl, M.C.
• Format: Journal Article
• Language: English
• Published: Scotland Elsevier Ltd 01.12.2015
• Subjects: Adolescent; Adult; Advanced Basic Science; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Anti-Inflammatory Agents, Non-Steroidal - metabolism; Body Mass Index; C-reactive protein; C-Reactive Protein - analysis; Dietary Supplements; Endocrinology & Metabolism; Fatty Acids, Omega-6 - administration & dosage; Fatty Acids, Omega-6 - analysis; Fatty Acids, Omega-6 - antagonists & inhibitors; Fatty Acids, Omega-6 - blood; Female; Fish Oils - administration & dosage; Fish Oils - metabolism; Gene-diet interaction; Genetic Association Studies; Group IV Phospholipases A2 - genetics; Group IV Phospholipases A2 - metabolism; Group VI Phospholipases A2 - genetics; Group VI Phospholipases A2 - metabolism; Humans; Inflammation; Male; Middle Aged; Nutrigenomics - methods; Omega-3 fatty acid; Omega-6 fatty acid; Overweight - blood; Overweight - genetics; Overweight - metabolism; Phospholipase A2; Phospholipids - blood; Phospholipids - chemistry; Polymorphism, Single Nucleotide; Quebec; Sex Characteristics; Young Adult; Quebec; AA; CRP; Gene-diet interaction; Phospholipase A2; C-reactive protein; PLA2; Inflammation; Δ CRP; Omega-6 fatty acid; SNP; EPA; Δ total n-6 FAs; HWE; Omega-3 fatty acid; DHA; arachidonic acid; single nucleotide polymorphism; phospholipase A2; changes in total n-6 FAs; changes in plasma CRP levels; eicosapentaenoic acid; Hardy–Weinberg equilibrium; docosahexaenoic acid; PLA 2
• ISSN: 0952-3278; 1532-2823; 1532-2823
• DOI: 10.1016/j.plefa.2015.10.002

This clinical trial investigated the impact of a six-week supplementation with fish oil and single nucleotide polymorphisms (SNPs) in PLA2G4A and PLA2G6 genes on total omega-6 fatty acid (n-6 FA) levels in plasma phospholipids (PL) and plasma C-reactive protein (CRP) levels in 191 subjects. Interaction effects between SNPs and supplementation modulated total n-6 FAs and CRP levels in both men and women. Associations between SNPs and total n-6 FA levels and between SNPs and CRP levels were identified in men, independently of supplementation. Supplementation decreased total n-6 FAs without affecting plasma CRP levels. Changes in CRP levels correlated positively with changes in total n-6 FAs in men (r=0.25 p=0.01), but not in women. In conclusion, total n-6 FA levels in plasma PL and plasma CRP levels are modulated by SNPs within PLA2G4A and PLA2G6 genes alone or in combination with fish oil supplementation.