Methyl gallate: Review of pharmacological activity

Methyl gallate (MG) is a polyphenolic compound widely found in natural plants. MG has been shown to have a variety of biological functions, including anti-tumor, anti-inflammatory, anti-oxidant, neuroprotective, hepatoprotective and anti-microbial activities, and has broad research and development p...

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Published inPharmacological research Vol. 194; p. 106849
Main Authors Liang, Huaguo, Huang, Qingsong, Zou, Li, Wei, Peng, Lu, Jiazheng, Zhang, Yongli
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.08.2023
Elsevier
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Abstract Methyl gallate (MG) is a polyphenolic compound widely found in natural plants. MG has been shown to have a variety of biological functions, including anti-tumor, anti-inflammatory, anti-oxidant, neuroprotective, hepatoprotective and anti-microbial activities, and has broad research and development prospects. A total of 88 articles related to MG were searched using the PubMed, Science Direct, and Google Scholar databases, systematically investigating the pharmacological activity and molecular mechanisms of MG. There were no restrictions on the publication years, and the last search was conducted on June 5, 2023. MG can exert pharmacological effects through multiple pathways and targets, such as PI3K/Akt, ERK1/2, Caspase, AMPK/NF-κB, Wnt/β-catenin, TLR4/NF-κB, MAPK, p53, NLRP3, ROS, EMT. According to the literature, MG has the potential to be a prospective adjuvant for anticancer therapy and deserves further study. [Display omitted] •MG exhibits a wide range of pharmacological activities, including anti-tumor, anti-inflammatory and anti-microbial effects.•MG exerts its anti-tumor effects through inducing cell apoptosis, inhibiting EMT, and modulating immune cells.•MG can also synergistically interact with other clinical drugs to exert pharmacological effects and reduce drug toxicity.
AbstractList Methyl gallate (MG) is a polyphenolic compound widely found in natural plants. MG has been shown to have a variety of biological functions, including anti-tumor, anti-inflammatory, anti-oxidant, neuroprotective, hepatoprotective and anti-microbial activities, and has broad research and development prospects. A total of 88 articles related to MG were searched using the PubMed, Science Direct, and Google Scholar databases, systematically investigating the pharmacological activity and molecular mechanisms of MG. There were no restrictions on the publication years, and the last search was conducted on June 5, 2023. MG can exert pharmacological effects through multiple pathways and targets, such as PI3K/Akt, ERK1/2, Caspase, AMPK/NF-κB, Wnt/β-catenin, TLR4/NF-κB, MAPK, p53, NLRP3, ROS, EMT. According to the literature, MG has the potential to be a prospective adjuvant for anticancer therapy and deserves further study.
Methyl gallate (MG) is a polyphenolic compound widely found in natural plants. MG has been shown to have a variety of biological functions, including anti-tumor, anti-inflammatory, anti-oxidant, neuroprotective, hepatoprotective and anti-microbial activities, and has broad research and development prospects. A total of 88 articles related to MG were searched using the PubMed, Science Direct, and Google Scholar databases, systematically investigating the pharmacological activity and molecular mechanisms of MG. There were no restrictions on the publication years, and the last search was conducted on June 5, 2023. MG can exert pharmacological effects through multiple pathways and targets, such as PI3K/Akt, ERK1/2, Caspase, AMPK/NF-κB, Wnt/β-catenin, TLR4/NF-κB, MAPK, p53, NLRP3, ROS, EMT. According to the literature, MG has the potential to be a prospective adjuvant for anticancer therapy and deserves further study. [Display omitted] •MG exhibits a wide range of pharmacological activities, including anti-tumor, anti-inflammatory and anti-microbial effects.•MG exerts its anti-tumor effects through inducing cell apoptosis, inhibiting EMT, and modulating immune cells.•MG can also synergistically interact with other clinical drugs to exert pharmacological effects and reduce drug toxicity.
Methyl gallate (MG) is a polyphenolic compound widely found in natural plants. MG has been shown to have a variety of biological functions, including anti-tumor, anti-inflammatory, anti-oxidant, neuroprotective, hepatoprotective and anti-microbial activities, and has broad research and development prospects. A total of 88 articles related to MG were searched using the PubMed, Science Direct, and Google Scholar databases, systematically investigating the pharmacological activity and molecular mechanisms of MG. There were no restrictions on the publication years, and the last search was conducted on June 5, 2023. MG can exert pharmacological effects through multiple pathways and targets, such as PI3K/Akt, ERK1/2, Caspase, AMPK/NF-κB, Wnt/β-catenin, TLR4/NF-κB, MAPK, p53, NLRP3, ROS, EMT. According to the literature, MG has the potential to be a prospective adjuvant for anticancer therapy and deserves further study.Methyl gallate (MG) is a polyphenolic compound widely found in natural plants. MG has been shown to have a variety of biological functions, including anti-tumor, anti-inflammatory, anti-oxidant, neuroprotective, hepatoprotective and anti-microbial activities, and has broad research and development prospects. A total of 88 articles related to MG were searched using the PubMed, Science Direct, and Google Scholar databases, systematically investigating the pharmacological activity and molecular mechanisms of MG. There were no restrictions on the publication years, and the last search was conducted on June 5, 2023. MG can exert pharmacological effects through multiple pathways and targets, such as PI3K/Akt, ERK1/2, Caspase, AMPK/NF-κB, Wnt/β-catenin, TLR4/NF-κB, MAPK, p53, NLRP3, ROS, EMT. According to the literature, MG has the potential to be a prospective adjuvant for anticancer therapy and deserves further study.
ArticleNumber 106849
Author Lu, Jiazheng
Zhang, Yongli
Zou, Li
Wei, Peng
Huang, Qingsong
Liang, Huaguo
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  surname: Liang
  fullname: Liang, Huaguo
  organization: School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou 510006, PR China
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  surname: Huang
  fullname: Huang, Qingsong
  organization: School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou 510006, PR China
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  givenname: Li
  surname: Zou
  fullname: Zou, Li
  organization: School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China
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  surname: Wei
  fullname: Wei, Peng
  organization: School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou 510006, PR China
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  givenname: Jiazheng
  surname: Lu
  fullname: Lu, Jiazheng
  organization: School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China
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  surname: Zhang
  fullname: Zhang, Yongli
  email: zyl28_gdpu@163.com
  organization: School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou 510006, PR China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/37429335$$D View this record in MEDLINE/PubMed
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Keywords PGD2
RANKL
UGT
Anti-tumor
Anti-oxidant
t-BHP
ClpP
HIF-1α
HSV-2
UPLC–MS/MS
NF-κB
ADAMTS5
BSA
PI3K
MRSA
mTOR
iNOS
MG
Ty
MIC
HCC
AIDS
MAPK
EMT
IL-6
PPARγ
MMP
ROS
AMPK
TLR4
Anti-inflammatory
BMMC
ERK
Bcl-2
NO
Methyl gallate
COX-2
Anti-microbial
1-NP
PARP
HO-1
LPS
PRDX3
SD
OA
Nrf2
NLRP3
Bid
GSK
Tregs
ATPase
VEGF
STAT3
MMPs
NMG
Akt
VCAM-1
TNF-α
HIV
ZIF
DNA
LTC4
Language English
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Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
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Snippet Methyl gallate (MG) is a polyphenolic compound widely found in natural plants. MG has been shown to have a variety of biological functions, including...
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StartPage 106849
SubjectTerms Anti-inflammatory
Anti-microbial
Anti-oxidant
Anti-tumor
Methyl gallate
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Title Methyl gallate: Review of pharmacological activity
URI https://dx.doi.org/10.1016/j.phrs.2023.106849
https://www.ncbi.nlm.nih.gov/pubmed/37429335
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Volume 194
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