Methyl gallate: Review of pharmacological activity
Methyl gallate (MG) is a polyphenolic compound widely found in natural plants. MG has been shown to have a variety of biological functions, including anti-tumor, anti-inflammatory, anti-oxidant, neuroprotective, hepatoprotective and anti-microbial activities, and has broad research and development p...
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Published in | Pharmacological research Vol. 194; p. 106849 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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Elsevier Ltd
01.08.2023
Elsevier |
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Abstract | Methyl gallate (MG) is a polyphenolic compound widely found in natural plants. MG has been shown to have a variety of biological functions, including anti-tumor, anti-inflammatory, anti-oxidant, neuroprotective, hepatoprotective and anti-microbial activities, and has broad research and development prospects. A total of 88 articles related to MG were searched using the PubMed, Science Direct, and Google Scholar databases, systematically investigating the pharmacological activity and molecular mechanisms of MG. There were no restrictions on the publication years, and the last search was conducted on June 5, 2023. MG can exert pharmacological effects through multiple pathways and targets, such as PI3K/Akt, ERK1/2, Caspase, AMPK/NF-κB, Wnt/β-catenin, TLR4/NF-κB, MAPK, p53, NLRP3, ROS, EMT. According to the literature, MG has the potential to be a prospective adjuvant for anticancer therapy and deserves further study.
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•MG exhibits a wide range of pharmacological activities, including anti-tumor, anti-inflammatory and anti-microbial effects.•MG exerts its anti-tumor effects through inducing cell apoptosis, inhibiting EMT, and modulating immune cells.•MG can also synergistically interact with other clinical drugs to exert pharmacological effects and reduce drug toxicity. |
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AbstractList | Methyl gallate (MG) is a polyphenolic compound widely found in natural plants. MG has been shown to have a variety of biological functions, including anti-tumor, anti-inflammatory, anti-oxidant, neuroprotective, hepatoprotective and anti-microbial activities, and has broad research and development prospects. A total of 88 articles related to MG were searched using the PubMed, Science Direct, and Google Scholar databases, systematically investigating the pharmacological activity and molecular mechanisms of MG. There were no restrictions on the publication years, and the last search was conducted on June 5, 2023. MG can exert pharmacological effects through multiple pathways and targets, such as PI3K/Akt, ERK1/2, Caspase, AMPK/NF-κB, Wnt/β-catenin, TLR4/NF-κB, MAPK, p53, NLRP3, ROS, EMT. According to the literature, MG has the potential to be a prospective adjuvant for anticancer therapy and deserves further study. Methyl gallate (MG) is a polyphenolic compound widely found in natural plants. MG has been shown to have a variety of biological functions, including anti-tumor, anti-inflammatory, anti-oxidant, neuroprotective, hepatoprotective and anti-microbial activities, and has broad research and development prospects. A total of 88 articles related to MG were searched using the PubMed, Science Direct, and Google Scholar databases, systematically investigating the pharmacological activity and molecular mechanisms of MG. There were no restrictions on the publication years, and the last search was conducted on June 5, 2023. MG can exert pharmacological effects through multiple pathways and targets, such as PI3K/Akt, ERK1/2, Caspase, AMPK/NF-κB, Wnt/β-catenin, TLR4/NF-κB, MAPK, p53, NLRP3, ROS, EMT. According to the literature, MG has the potential to be a prospective adjuvant for anticancer therapy and deserves further study. [Display omitted] •MG exhibits a wide range of pharmacological activities, including anti-tumor, anti-inflammatory and anti-microbial effects.•MG exerts its anti-tumor effects through inducing cell apoptosis, inhibiting EMT, and modulating immune cells.•MG can also synergistically interact with other clinical drugs to exert pharmacological effects and reduce drug toxicity. Methyl gallate (MG) is a polyphenolic compound widely found in natural plants. MG has been shown to have a variety of biological functions, including anti-tumor, anti-inflammatory, anti-oxidant, neuroprotective, hepatoprotective and anti-microbial activities, and has broad research and development prospects. A total of 88 articles related to MG were searched using the PubMed, Science Direct, and Google Scholar databases, systematically investigating the pharmacological activity and molecular mechanisms of MG. There were no restrictions on the publication years, and the last search was conducted on June 5, 2023. MG can exert pharmacological effects through multiple pathways and targets, such as PI3K/Akt, ERK1/2, Caspase, AMPK/NF-κB, Wnt/β-catenin, TLR4/NF-κB, MAPK, p53, NLRP3, ROS, EMT. According to the literature, MG has the potential to be a prospective adjuvant for anticancer therapy and deserves further study.Methyl gallate (MG) is a polyphenolic compound widely found in natural plants. MG has been shown to have a variety of biological functions, including anti-tumor, anti-inflammatory, anti-oxidant, neuroprotective, hepatoprotective and anti-microbial activities, and has broad research and development prospects. A total of 88 articles related to MG were searched using the PubMed, Science Direct, and Google Scholar databases, systematically investigating the pharmacological activity and molecular mechanisms of MG. There were no restrictions on the publication years, and the last search was conducted on June 5, 2023. MG can exert pharmacological effects through multiple pathways and targets, such as PI3K/Akt, ERK1/2, Caspase, AMPK/NF-κB, Wnt/β-catenin, TLR4/NF-κB, MAPK, p53, NLRP3, ROS, EMT. According to the literature, MG has the potential to be a prospective adjuvant for anticancer therapy and deserves further study. |
ArticleNumber | 106849 |
Author | Lu, Jiazheng Zhang, Yongli Zou, Li Wei, Peng Huang, Qingsong Liang, Huaguo |
Author_xml | – sequence: 1 givenname: Huaguo surname: Liang fullname: Liang, Huaguo organization: School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou 510006, PR China – sequence: 2 givenname: Qingsong surname: Huang fullname: Huang, Qingsong organization: School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou 510006, PR China – sequence: 3 givenname: Li surname: Zou fullname: Zou, Li organization: School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China – sequence: 4 givenname: Peng surname: Wei fullname: Wei, Peng organization: School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou 510006, PR China – sequence: 5 givenname: Jiazheng surname: Lu fullname: Lu, Jiazheng organization: School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China – sequence: 6 givenname: Yongli surname: Zhang fullname: Zhang, Yongli email: zyl28_gdpu@163.com organization: School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou 510006, PR China |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37429335$$D View this record in MEDLINE/PubMed |
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