Methyl gallate: Review of pharmacological activity

• Published in: Pharmacological research Vol. 194; p. 106849
• Main Authors: Liang, Huaguo, Huang, Qingsong, Zou, Li, Wei, Peng, Lu, Jiazheng, Zhang, Yongli
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.08.2023; Elsevier
• Subjects: Anti-inflammatory; Anti-microbial; Anti-oxidant; Anti-tumor; Methyl gallate; PGD2; RANKL; UGT; Anti-tumor; Anti-oxidant; t-BHP; ClpP; HIF-1α; HSV-2; UPLC–MS/MS; NF-κB; ADAMTS5; BSA; PI3K; MRSA; mTOR; iNOS; MG; Ty; MIC; HCC; AIDS; MAPK; EMT; IL-6; PPARγ; MMP; ROS; AMPK; TLR4; Anti-inflammatory; BMMC; ERK; Bcl-2; NO; Methyl gallate; COX-2; Anti-microbial; 1-NP; PARP; HO-1; LPS; PRDX3; SD; OA; Nrf2; NLRP3; Bid; GSK; Tregs; ATPase; VEGF; STAT3; MMPs; NMG; Akt; VCAM-1; TNF-α; HIV; ZIF; DNA; LTC4
• ISSN: 1043-6618; 1096-1186; 1096-1186
• DOI: 10.1016/j.phrs.2023.106849

Methyl gallate (MG) is a polyphenolic compound widely found in natural plants. MG has been shown to have a variety of biological functions, including anti-tumor, anti-inflammatory, anti-oxidant, neuroprotective, hepatoprotective and anti-microbial activities, and has broad research and development prospects. A total of 88 articles related to MG were searched using the PubMed, Science Direct, and Google Scholar databases, systematically investigating the pharmacological activity and molecular mechanisms of MG. There were no restrictions on the publication years, and the last search was conducted on June 5, 2023. MG can exert pharmacological effects through multiple pathways and targets, such as PI3K/Akt, ERK1/2, Caspase, AMPK/NF-κB, Wnt/β-catenin, TLR4/NF-κB, MAPK, p53, NLRP3, ROS, EMT. According to the literature, MG has the potential to be a prospective adjuvant for anticancer therapy and deserves further study. [Display omitted] •MG exhibits a wide range of pharmacological activities, including anti-tumor, anti-inflammatory and anti-microbial effects.•MG exerts its anti-tumor effects through inducing cell apoptosis, inhibiting EMT, and modulating immune cells.•MG can also synergistically interact with other clinical drugs to exert pharmacological effects and reduce drug toxicity.