A Subset of Cancer-Associated Fibroblasts Determines Therapy Resistance

While functional heterogeneity of fibroblastic cells populating the tumor microenvironment is increasingly recognized, lack of definitive markers complicates elucidation of roles among ostensibly distinctive fibroblastic states. In this issue of Cell, Su et al. characterize a new pro-tumorigenic can...

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Bibliographic Details
Published inCell Vol. 172; no. 4; pp. 643 - 644
Main Authors Huelsken, Joerg, Hanahan, Douglas
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 08.02.2018
Subjects
Cancer-Associated Fibroblasts
Carcinogenesis
Fibroblasts
Humans
Signal Transduction
Tumor Microenvironment
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Summary:While functional heterogeneity of fibroblastic cells populating the tumor microenvironment is increasingly recognized, lack of definitive markers complicates elucidation of roles among ostensibly distinctive fibroblastic states. In this issue of Cell, Su et al. characterize a new pro-tumorigenic cancer-associated fibroblast subset mediating chemoresistance defined and driven by a novel signaling pathway. While functional heterogeneity of fibroblastic cells populating the tumor microenvironment is increasingly recognized, lack of definitive markers complicates elucidation of roles among ostensibly distinctive fibroblastic states. In this issue of Cell, Su et al. characterize a new pro-tumorigenic cancer-associated fibroblast subset mediating chemoresistance defined and driven by a novel signaling pathway.
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ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2018.01.028