Gene Regulation and Quality Control in Murine Polyomavirus Infection

• Published in: Viruses Vol. 8; no. 10; p. 284
• Main Author: Carmichael, Gordon G
• Format: Journal Article Book Review
• Language: English
• Published: Switzerland MDPI AG 17.10.2016; MDPI
• Subjects: Animals; Gene Expression Regulation; Host-Pathogen Interactions; Mice; nuclear retention; Polyomavirus - immunology; Polyomavirus - physiology; quality control; Review; RNA decay; RNA editing; transcription; Virus Replication; RNA decay; RNA editing; quality control; transcription; nuclear retention

Murine polyomavirus (MPyV) infects mouse cells and is highly oncogenic in immunocompromised hosts and in other rodents. Its genome is a small, circular DNA molecule of just over 5000 base pairs and it encodes only seven polypeptides. While seemingly simply organized, this virus has adopted an unusua...