Gene Regulation and Quality Control in Murine Polyomavirus Infection

Murine polyomavirus (MPyV) infects mouse cells and is highly oncogenic in immunocompromised hosts and in other rodents. Its genome is a small, circular DNA molecule of just over 5000 base pairs and it encodes only seven polypeptides. While seemingly simply organized, this virus has adopted an unusua...

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Bibliographic Details
Published inViruses Vol. 8; no. 10; p. 284
Main Author Carmichael, Gordon G
Format Journal Article Book Review
LanguageEnglish
Published Switzerland MDPI AG 17.10.2016
MDPI
Subjects
Animals
Gene Expression Regulation
Host-Pathogen Interactions
Mice
nuclear retention
Polyomavirus - immunology
Polyomavirus - physiology
quality control
Review
RNA decay
RNA editing
transcription
Virus Replication
RNA decay
RNA editing
quality control
transcription
nuclear retention
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Summary:Murine polyomavirus (MPyV) infects mouse cells and is highly oncogenic in immunocompromised hosts and in other rodents. Its genome is a small, circular DNA molecule of just over 5000 base pairs and it encodes only seven polypeptides. While seemingly simply organized, this virus has adopted an unusual genome structure and some unusual uses of cellular quality control pathways that, together, allow an amazingly complex and varied pattern of gene regulation. In this review we discuss how MPyV leverages these various pathways to control its life cycle.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:1999-4915
1999-4915
DOI:10.3390/v8100284