Thresholds for indirect DNA damage across cellular barriers for orthopaedic biomaterials

Abstract Cobalt–chromium particles and ions can induce indirect DNA damage and chromosome aberrations in human cells on the other side of a cellular barrier in tissue culture. This occurs by intercellular signalling across the barrier. We now show that the threshold for this effect depends on the me...

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Published inBiomaterials Vol. 31; no. 16; pp. 4477 - 4483
Main Authors Parry, Michael C, Bhabra, Gevdeep, Sood, Aman, Machado, Filipa, Cartwright, Laura, Saunders, Margaret, Ingham, E, Newson, R, Blom, Ashley W, Case, Charles P
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.06.2010
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Abstract Abstract Cobalt–chromium particles and ions can induce indirect DNA damage and chromosome aberrations in human cells on the other side of a cellular barrier in tissue culture. This occurs by intercellular signalling across the barrier. We now show that the threshold for this effect depends on the metal form and the particle composition. Ionic cobalt and chromium induced single strand breaks at concentrations equivalent to those found in the blood of patients with well functioning metal on metal hip prostheses. However, they only caused double strand breaks if the chromium was present as chromium (VI), and did not induce chromosome aberrations. Nanoparticles of cobalt–chromium alloy caused DNA double strand breaks and chromosome aberrations, of which the majority were tetraploidy. Ceramic nanoparticles induced only single strand breaks and/or alkaline labile sites when indirectly exposed to human fibroblasts. The assessment of reproductive risk from maternal exposure to biomaterials is not yet possible with epidemiology. Whilst the barrier model used here differs from the in vivo situation in several respects, it may be useful as a framework to evaluate biomaterial induced damage across physiological barriers.
AbstractList Cobalt–chromium particles and ions can induce indirect DNA damage and chromosome aberrations in human cells on the other side of a cellular barrier in tissue culture. This occurs by intercellular signalling across the barrier. We now show that the threshold for this effect depends on the metal form and the particle composition. Ionic cobalt and chromium induced single strand breaks at concentrations equivalent to those found in the blood of patients with well functioning metal on metal hip prostheses. However, they only caused double strand breaks if the chromium was present as chromium (VI), and did not induce chromosome aberrations. Nanoparticles of cobalt–chromium alloy caused DNA double strand breaks and chromosome aberrations, of which the majority were tetraploidy. Ceramic nanoparticles induced only single strand breaks and/or alkaline labile sites when indirectly exposed to human fibroblasts. The assessment of reproductive risk from maternal exposure to biomaterials is not yet possible with epidemiology. Whilst the barrier model used here differs from the in vivo situation in several respects, it may be useful as a framework to evaluate biomaterial induced damage across physiological barriers.
Abstract Cobalt–chromium particles and ions can induce indirect DNA damage and chromosome aberrations in human cells on the other side of a cellular barrier in tissue culture. This occurs by intercellular signalling across the barrier. We now show that the threshold for this effect depends on the metal form and the particle composition. Ionic cobalt and chromium induced single strand breaks at concentrations equivalent to those found in the blood of patients with well functioning metal on metal hip prostheses. However, they only caused double strand breaks if the chromium was present as chromium (VI), and did not induce chromosome aberrations. Nanoparticles of cobalt–chromium alloy caused DNA double strand breaks and chromosome aberrations, of which the majority were tetraploidy. Ceramic nanoparticles induced only single strand breaks and/or alkaline labile sites when indirectly exposed to human fibroblasts. The assessment of reproductive risk from maternal exposure to biomaterials is not yet possible with epidemiology. Whilst the barrier model used here differs from the in vivo situation in several respects, it may be useful as a framework to evaluate biomaterial induced damage across physiological barriers.
Author Machado, Filipa
Blom, Ashley W
Ingham, E
Sood, Aman
Saunders, Margaret
Bhabra, Gevdeep
Cartwright, Laura
Newson, R
Case, Charles P
Parry, Michael C
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/20227759$$D View this record in MEDLINE/PubMed
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Issue 16
Keywords Cell signalling
Arthroplasty
Nanoparticle
Reproductive toxicity
Cobalt alloy
Genotoxicity
Language English
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Snippet Abstract Cobalt–chromium particles and ions can induce indirect DNA damage and chromosome aberrations in human cells on the other side of a cellular barrier in...
Cobalt–chromium particles and ions can induce indirect DNA damage and chromosome aberrations in human cells on the other side of a cellular barrier in tissue...
Cobalt-chromium particles and ions can induce indirect DNA damage and chromosome aberrations in human cells on the other side of a cellular barrier in tissue...
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SubjectTerms Advanced Basic Science
Alloys - chemistry
Alloys - pharmacology
Animals
Arthroplasty
Arthroplasty, Replacement, Hip
Biocompatible Materials - pharmacology
Cell signalling
Cells, Cultured
Ceramics - chemistry
Ceramics - pharmacology
Chromium - chemistry
Chromium - pharmacology
Chromosome Aberrations - chemically induced
Cobalt - chemistry
Cobalt - pharmacology
Cobalt alloy
Dentistry
DNA - drug effects
DNA Damage
Female
Fibroblasts - cytology
Fibroblasts - drug effects
Fibroblasts - physiology
Genotoxicity
Humans
Karyotyping
Materials Testing
Metal Nanoparticles - chemistry
Nanoparticle
Orthopedics
Placenta - cytology
Placenta - drug effects
Placenta - metabolism
Pregnancy
Reproductive toxicity
Title Thresholds for indirect DNA damage across cellular barriers for orthopaedic biomaterials
URI https://www.clinicalkey.es/playcontent/1-s2.0-S014296121000267X
https://dx.doi.org/10.1016/j.biomaterials.2010.02.038
https://www.ncbi.nlm.nih.gov/pubmed/20227759
https://search.proquest.com/docview/877570058
Volume 31
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