Simultaneous Chronoamperometric Sensing of Ascorbic Acid and Acetaminophen at a Boron-Doped Diamond Electrode

Cyclic voltammetry (CV) and chronoamperometry (CA) have been used to sense and determine simultaneously L-ascorbic acid (AA) and acetaminophen (AC) at a boron-doped diamond electrode (BDDE) in a Britton-Robinson buffer solution. The calibration plots of anodic current peak versus concentration obtai...

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Published inSensors (Basel, Switzerland) Vol. 8; no. 6; pp. 3952 - 3969
Main Authors Cofan, Codruţa, Radovan, Ciprian
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 12.06.2008
Molecular Diversity Preservation International (MDPI)
Subjects
acetaminophen
Acids
Analgesics
ascorbic acid
Boron
boron-doped diamond electrode
buffered media
Chromatography
chronoamperometry
Electrodes
Electrolytes
Electrons
Investigations
Oxidation
Pharmaceuticals
Sensors
Toxicity
Voltammetry
buffered media
boron-doped diamond electrode
chronoamperometry
acetaminophen
ascorbic acid
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Summary:Cyclic voltammetry (CV) and chronoamperometry (CA) have been used to sense and determine simultaneously L-ascorbic acid (AA) and acetaminophen (AC) at a boron-doped diamond electrode (BDDE) in a Britton-Robinson buffer solution. The calibration plots of anodic current peak versus concentration obtained from CV and CA data for both investigated compounds in single and di-component solutions over the concentration range 0.01 mM - 0.1 mM proved to be linear, with very good correlation parameters. Sensitivity values and RSD of 2-3% were obtained for various situations, involving both individual and simultaneous presence of AA and AC. The chronoamperometric technique associated with standard addition in sequential one step and/or two successive and continuous chronoamperograms at two characteristic potential levels represented a feasible option for the simultaneous determination of AA and AC in real sample systems such as pharmaceutical formulations. The average values indicated by the supplier were confirmed to a very close approximation from chronoamperomgrams by using several additions with the application of suitable current correction factors.
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ISSN:1424-8220
1424-8220
DOI:10.3390/s8063952