Emerging roles of circular RNAs in cancer therapy-induced cardiotoxicity

Cancer therapy-induced cardiotoxicity (CTIC) is an important cause of death in cancer survivors which often results in the withdrawal or discontinuation of drugs. The underlying mechanisms of CTIC remain unclear. Circular RNAs (circRNAs) are a class of non-coding regulatory RNA molecules which have...

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Published inFrontiers in cardiovascular medicine Vol. 10; p. 1152436
Main Authors Cheng, Ziji, Qin, Wanting, Li, Shaoling, Shao, Shuijin, Liu, Baonian
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 20.03.2023
Subjects
biomaker
cancer therapy-induced cardiotoxicity
Cardiovascular Medicine
circRNA
doxorubicin
therapeutic target
therapeutic target
doxorubicin
circRNA
biomaker
cancer therapy-induced cardiotoxicity
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Summary:Cancer therapy-induced cardiotoxicity (CTIC) is an important cause of death in cancer survivors which often results in the withdrawal or discontinuation of drugs. The underlying mechanisms of CTIC remain unclear. Circular RNAs (circRNAs) are a class of non-coding regulatory RNA molecules which have emerged in recent years. They are generated by back splicing and have powerful biological functions, including transcription and splicing, isolating or building macromolecular scaffolds to interfere with microRNA activity and signaling pathways, and acting as templates for translation. Moreover, circRNAs demonstrate high abundance and significant stability. CircRNAs can be used as novel biomarkers because they often function in a cell-type and tissue-specific manner. CircRNAs have attracted increasing attention in cardiovascular disease research, and recent studies exploring the role of circRNAs in CTIC have had promising results. This review will summarize the current understanding of circRNAs' biogenesis, regulation and function. Their clinical potential as biomarkers, therapeutic agents and drug targets will also be explored.
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Reviewed by: Massimo Baudo, Spedali Civili Brescia, Italy Dongchao Lu, Hannover Medical School, Germany Xiaolin Wang, University of Science and Technology of China, China
Specialty Section: This article was submitted to Cardio-Oncology, a section of the journal Frontiers in Cardiovascular Medicine
These authors have contributed equally to this work
Edited by: Mohamed Rahouma, NewYork-Presbyterian, United States
ISSN:2297-055X
2297-055X
DOI:10.3389/fcvm.2023.1152436