Antagonistic interaction between MAP kinase and protein phosphatase 2C in stress recovery

The Arabidopsis mitogen-activated kinase MPK6 transmits a diversity of stress signals. However, much less is known about resetting mechanisms subsequent to the stress response. We show that MPK6 is a potential target of abscisic acid-insensitive 1 (ABI1), a protein phosphatase 2C that acts as a key...

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Published inPlant science (Limerick) Vol. 171; no. 5; pp. 596 - 606
Main Authors Leung, Jeffrey, Orfanidi, Sofia, Chefdor, Françoise, Mészaros, Tamás, Bolte, Susanne, Mizoguchi, Tsuyoshi, Shinozaki, Kazuo, Giraudat, Jérôme, Bögre, Laszlo
Format Journal Article
LanguageEnglish
Published Shannon Elsevier Ireland Ltd 01.11.2006
Elsevier Science
Elsevier
Subjects
Abscisic acid
Arabidopsis thaliana
Biological and medical sciences
Cross-talk
Enzymes
Ethylene
Fundamental and applied biological sciences. Psychology
Life Sciences
Metabolism
mitogen-associated protein kinases
phosphoprotein phosphatase
Plant physiology and development
protein kinases
protein-protein interactions
sbscisic acid-insensitive1 protein
signal transduction
transgenes
Vegetal Biology
ABA
Abscisic acid
MPK
PP2C
Cross-talk
Ethylene
Enzyme
Phosphoprotein phosphatase
Phosphoric monoester hydrolases
Mitogen-activated protein kinase
Hydrolases
Esterases
Stress
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Summary:The Arabidopsis mitogen-activated kinase MPK6 transmits a diversity of stress signals. However, much less is known about resetting mechanisms subsequent to the stress response. We show that MPK6 is a potential target of abscisic acid-insensitive 1 (ABI1), a protein phosphatase 2C that acts as a key element in attenuating abscisic acid (ABA)-dependent stress signaling. MPK6 can bind to ABI1 in vitro and in yeast, and that a complex containing these two proteins can be co-precipitated from transfected Arabidopsis cells. In whole plants, MPK6 is hyper-reactive to osmotic stress in mutants compromised in ABI1 activity, but not in its closest functional homolog ABI2. Moreover, conditional expression of a dominant-negative form of mpk6 renders plants hypersensitive to ABA. MPK6 enhances the synthesis of ethylene [1]. ABI1 may therefore down modulate ethylene as part of the resetting mechanism after stress.
Bibliography:http://dx.doi.org/10.1016/j.plantsci.2006.06.009
ISSN:0168-9452
1873-2259
DOI:10.1016/j.plantsci.2006.06.009