Formulation and evaluation of albumin microspheres and its enteric coating using a spray-dryer

This study optimized and evaluated the conditions for surface coating of microspheres using a spray-dryer. Four formulations of Bromophenol blue (BPB)-loaded albumin microspheres were prepared using a spray-dryer, cross-linked at different concentrations and time periods. One of the optimized formul...

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Bibliographic Details
Published inJournal of microencapsulation Vol. 25; no. 8; pp. 577 - 583
Main Authors Bejugam, Naveen K., Uddin, Akm N., Gayakwad, Sanjay G., D'Souza, Martin J.
Format Journal Article
LanguageEnglish
Published Colchester Informa UK Ltd 01.12.2008
Taylor & Francis
Informa
Subjects
Acrylic Resins - chemistry
Acrylic Resins - therapeutic use
albumin
Albumins
Biological and medical sciences
Bromphenol Blue - administration & dosage
Coated Materials, Biocompatible - chemistry
Coloring Agents - administration & dosage
Delayed-Action Preparations - chemistry
enteric polymer
Gastrointestinal Contents
General pharmacology
Medical sciences
Microspheres
Particle Size
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
spray-dryer
Surface coating
Evaluation
Microsphere
Pharmaceutical technology
spray-dryer
Surface coating
microspheres
Albumin
Polymer
Enteric coating
enteric polymer
Formulation
Dosage form
Microparticle
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Summary:This study optimized and evaluated the conditions for surface coating of microspheres using a spray-dryer. Four formulations of Bromophenol blue (BPB)-loaded albumin microspheres were prepared using a spray-dryer, cross-linked at different concentrations and time periods. One of the optimized formulations with the desired characteristics was selected for enteric coating with Eudragit L100-55®. The procedure involved suspending BPB microspheres in polymer solution and spray-drying it. Four enteric coated formulations were prepared with different concentrations of microspheres in suspension (0.25 and 0.5%w/v) and polymer concentrations (0.25 and 0.5%w/v). Change in the mean particle size after coating was determined using a Laser Particle Counter. The surface coating technique employed did not significantly increase the particle size. Enteric coating efficiency was determined in simulated gastric fluid. Compared to the uncoated microspheres the cumulative amount of drug released from coated microspheres was significantly lower for 3 h, implying efficient surface coating.
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ISSN:0265-2048
1464-5246
DOI:10.1080/02652040802476187