The effects of diuretic use and the presence of ascites on muscle cramps in patients with cirrhosis: a nationwide study

• Published in: Journal of gastroenterology Vol. 55; no. 9; pp. 868 - 876
• Main Authors: Sawada, Yasuhiko, Shiraki, Makoto, Iwasa, Motoh, Hiraoka, Atsushi, Nakanishi, Hiroyuki, Karino, Yoshiyasu, Nakajima, Tomoaki, Miyaaki, Hisamitsu, Kawaguchi, Takumi, Yoshiji, Hitoshi, Okita, Kiwamu, Koike, Kazuhiko
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.09.2020; Springer; Springer Nature B.V
• Subjects: Abdominal Surgery; Analysis; Ascites; Biliary Tract; Care and treatment; Cirrhosis; Colorectal Surgery; Complications and side effects; Diuretics; Gastroenterology; Hepatology; Liver cirrhosis; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Multivariate analysis; Muscle cramps; Muscle pain; Original Article—Liver; Pancreas; Patients; Surgical Oncology; Muscle cramps; Diuretics; Liver cirrhosis; Extracellular water ratio
• ISSN: 0944-1174; 1435-5922
• DOI: 10.1007/s00535-020-01694-8

Background Administration of diuretics and the presence of ascites in patients with cirrhosis were reported to be associated with muscle cramps; however, the clinical evidence is limited. This study aimed to determine whether muscle cramps are a diuretic-induced complication and whether ascites was a factor related to muscle cramp. Methods A total of 1064 adult patients with cirrhosis were enrolled from 10 hospitals in Japan between June 2017 and December 2018. A questionnaire regarding cramps was completed by all patients. The ratio of extracellular water (ECW) was analyzed using the bioelectrical impedance analysis. Logistic regression analysis was performed to analyze the effects of diuretic administration and the ECW ratio on cramps. Results Patients using diuretics had a higher incidence rate, higher frequency, stronger pain, and longer duration of cramps than those who did not. In the multivariate analysis, diuretic administration and the ECW ratio values ≥ 0.4 were not significantly associated with the presence, frequency, intensity, or duration of cramps. However, in the case of patients limited to Child–Pugh B or C, diuretic use was significantly correlated with the cramp frequency. Conclusions These results demonstrated that muscle cramps were not a complication of diuretic use in patients with cirrhosis; however, in those limited to Child–Pugh B or C, diuretic use was a factor that affected the frequency of cramps. Moreover, no association was found between the presence of ascites and cramps.