Initial low-dose computed tomography screening results and summary of participant characteristics: based on the latest Chinese guideline

Low-dose computed tomography (LDCT) has been promoted as a promising screening strategy for early detection of lung cancer. China released the latest lung cancer screening guideline in 2021. The compliance of the individuals who received LDCT for lung cancer screening with the guideline is unknown y...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in oncology Vol. 13; p. 1085434
Main Authors Zhang, Zixuan, Gao, Yinyan, Liu, Shaohui, Ding, Binrong, Zhang, Xuewei, Wu, Irene X Y
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 24.05.2023
Subjects
Online AccessGet full text

Cover

Loading…
More Information
Summary:Low-dose computed tomography (LDCT) has been promoted as a promising screening strategy for early detection of lung cancer. China released the latest lung cancer screening guideline in 2021. The compliance of the individuals who received LDCT for lung cancer screening with the guideline is unknown yet. It is necessary to summarize the distribution of guideline-defined lung cancer-related risk factors in the Chinese population so as to inform the selection of target population for the future lung cancer screening. A single-center, cross-sectional study design was adopted. All participants were individuals who underwent LDCT at a tertiary teaching hospital in Hunan, China, between 1 January and 31 December 2021. LDCT results were derived along with guideline-based characteristics for descriptive analysis. A total of 5,486 participants were included. Over one-quarter (1,426, 26.0%) of the participants who received screening did not meet the guideline-defined high-risk population, even among non-smokers (36.4%). Most of the participants (4,622, 84.3%) were found to have lung nodules, while no clinical intervention was required basically. The detection rate of positive nodules varied from 46.8% to 71.2% when using different cut-off values for positive nodules. Among non-smoking women, ground glass opacity appeared to be more significantly common compared with non-smoking men (26.7% vs. 21.8%). Over one-quarter of individuals who received LDCT screening did not meet the guideline-defined high-risk populations. Appropriate cut-off values for positive nodules need to be continuously explored. More precise and localized criteria for high-risk individuals are needed, especially for non-smoking women.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Reviewed by: Xiaoyan Xin, Nanjing Drum Tower Hospital, China; Yan Kang, Shenzhen Technology University, China
Edited by: Chiara Martini, University Hospital of Parma, Italy
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2023.1085434