The role of micro-ribonucleic acids in normal hematopoiesis and leukemic T-lymphogenesis

Micro-ribonucleic acids (microRNAs) are small molecules containing 20-23 nucleotides. Despite their small size, it is likely that almost every cellular process is regulated by them. Moreover, aberrant microRNA expression has been involved in the development of various diseases, including cancer. Alt...

Full description

Saved in:
Bibliographic Details
Published inBrazilian journal of medical and biological research Vol. 43; no. 7; pp. 619 - 626
Main Authors Slavov, S N, Gimenes Teixeira, H L, Rego, E M
Format Journal Article
LanguageEnglish
Portuguese
Published Brazil Associação Brasileira de Divulgação Científica 01.07.2010
Subjects
Acute lymphoblastic leukemia
BIOLOGY
Biomarkers, Tumor - genetics
Gene expression
Gene Expression Regulation, Leukemic - genetics
Hematopoiesis - genetics
Humans
Leukemia
MEDICINE, RESEARCH & EXPERIMENTAL
MicroRNAs
MicroRNAs - genetics
MicroRNAs - physiology
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology
RNA, Neoplasm - genetics
T cells
Acute lymphoblastic leukemia
Gene expression
T cells
MicroRNAs
Leukemia
Online AccessGet full text

Cover

More Information
Summary:Micro-ribonucleic acids (microRNAs) are small molecules containing 20-23 nucleotides. Despite their small size, it is likely that almost every cellular process is regulated by them. Moreover, aberrant microRNA expression has been involved in the development of various diseases, including cancer. Although many data are available about the role of microRNAs in various lymphoproliferative disorders, their impact on the development of acute lymphoblastic leukemia of T-cell progenitors is largely unknown. In this review, we present recent information about how specific microRNAs are expressed and regulated during malignant T-lymphopoiesis and about their role during normal hematopoiesis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0100-879X
1414-431X
1414-431X
0100-879X
DOI:10.1590/S0100-879X2010007500057