Moisture-Induced Amorphous Phase Separation of Amorphous Solid Dispersions: Molecular Mechanism, Microstructure, and Its Impact on Dissolution Performance

• Published in: Journal of pharmaceutical sciences Vol. 107; no. 1; pp. 317 - 326
• Main Authors: Chen, Huijun, Pui, Yipshu, Liu, Chengyu, Chen, Zhen, Su, Ching-Chiang, Hageman, Michael, Hussain, Munir, Haskell, Roy, Stefanski, Kevin, Foster, Kimberly, Gudmundsson, Olafur, Qian, Feng
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2018
• Subjects: amorphous; Crystallization - methods; dissolution rate; Drug Liberation - drug effects; Drug Stability; drug-excipient interaction; Humidity; Hydrophobic and Hydrophilic Interactions; physical stability; Polymers - chemistry; Polyvinyls - chemistry; Pyrrolidines - chemistry; solid dispersion; Solubility; Urea - analogs & derivatives; Urea - chemistry; Valine - analogs & derivatives; Valine - chemistry; Water - chemistry; dissolution rate; amorphous; physical stability; solid dispersion; drug-excipient interaction
• ISSN: 0022-3549; 1520-6017
• DOI: 10.1016/j.xphs.2017.10.028

Amorphous phase separation (APS) is commonly observed in amorphous solid dispersions (ASD) when exposed to moisture. The objective of this study was to investigate: (1) the phase behavior of amorphous solid dispersions composed of a poorly water-soluble drug with extremely low crystallization propensity, BMS-817399, and PVP, following exposure to different relative humidity (RH), and (2) the impact of phase separation on the intrinsic dissolution rate of amorphous solid dispersion. Drug-polymer interaction was confirmed in ASDs at different drug loading using infrared (IR) spectroscopy and water vapor sorption analysis. It was found that the drug-polymer interaction could persist at low RH (≤75% RH) but was disrupted after exposure to high RH, with the advent of phase separation. Surface morphology and composition of 40/60 ASD at micro-/nano-scale before and after exposure to 95% RH were also compared. It was found that hydrophobic drug enriched on the surface of ASD after APS. However, for the 40/60 ASD system, the intrinsic dissolution rate of amorphous drug was hardly affected by the phase behavior of ASD, which may be partially attributed to the low crystallization tendency of amorphous BMS-817399 and enriched drug amount on the surface of ASD. Intrinsic dissolution rate of PVP decreased resulting from APS, leading to a lower concentration in the dissolution medium, but supersaturation maintenance was not anticipated to be altered after phase separation due to the limited ability of PVP to inhibit drug precipitation and prolong the supersaturation of drug in solution. This study indicated that for compounds with low crystallization propensity and high hydrophobicity, the risk of moisture-induced APS is high but such phase separation may not have profound impact on the drug dissolution performance of ASDs. Therefore, application of ASD technology on slow crystallizers could incur low risks not only in physical stability but also in dissolution performance.