The Origins and the Current Applications of Microfluidics-Based Magnetic Cell Separation Technologies

The magnetic separation of cells based on certain traits has a wide range of applications in microbiology, immunology, oncology, and hematology. Compared to bulk separation, performing magnetophoresis at micro scale presents advantages such as precise control of the environment, larger magnetic grad...

Full description

Saved in:
Bibliographic Details
Published inMagnetochemistry Vol. 8; no. 1; p. 10
Main Authors Civelekoglu, Ozgun, Frazier, A. Bruno, Sarioglu, A. Fatih
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.01.2022
Subjects
Blood
Breast cancer
cell separation
Cost analysis
Efficiency
Immunology
Magnetic fields
Magnetic separation
Magnetism
magnetophoresis
Microbiology
Microfluidics
Origins
Online AccessGet full text

Cover

More Information
Summary:The magnetic separation of cells based on certain traits has a wide range of applications in microbiology, immunology, oncology, and hematology. Compared to bulk separation, performing magnetophoresis at micro scale presents advantages such as precise control of the environment, larger magnetic gradients in miniaturized dimensions, operational simplicity, system portability, high-throughput analysis, and lower costs. Since the first integration of magnetophoresis and microfluidics, many different approaches have been proposed to magnetically separate cells from suspensions at the micro scale. This review paper aims to provide an overview of the origins of microfluidic devices for magnetic cell separation and the recent technologies and applications grouped by the targeted cell types. For each application, exemplary experimental methods and results are discussed.
ISSN:2312-7481
2312-7481
DOI:10.3390/magnetochemistry8010010