Calretinin expression in the mammalian neocortex: a review

In the mammalian neocortex, the calcium-binding protein calretinin is expressed in a subset of cortical interneurons. In the recent years, research on interneurons is one of the most rapidly growing fields in neuroscience. This review summarizes the actual knowledge of the functions of calretinin in...

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Bibliographic Details
Published inPhysiological research Vol. 59; no. 5; pp. 665 - 677
Main Authors Barinka, F, Druga, R
Format Journal Article
LanguageEnglish
Published Czech Republic Institute of Physiology 01.01.2010
Subjects
Animals
Calbindin 2
Gene expression
Homeostasis - physiology
Humans
Mammals
Neocortex - cytology
Neocortex - physiology
Neurons
Neurons - physiology
Proteins
Rodents
S100 Calcium Binding Protein G - physiology
Signal transduction
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Summary:In the mammalian neocortex, the calcium-binding protein calretinin is expressed in a subset of cortical interneurons. In the recent years, research on interneurons is one of the most rapidly growing fields in neuroscience. This review summarizes the actual knowledge of the functions of calretinin in neuronal homeostasis and particularly of the distribution, connectivity and physiological properties of calretinin expressing interneurons in the neocortex of rodents and primates, including humans. The possible neuroprotective role of calretinin and the presumed "resistance" of calretinin-expressing interneurons to various pathological processes are also discussed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0862-8408
1802-9973
DOI:10.33549/physiolres.931930