Comparison of the analytic sensitivities of a recombinant immunoblot assay and the radioimmune precipitation assay for the detection of antibodies to Trypanosoma cruzi in patients with Chagas disease

Abstract The diagnosis of chronic Chagas disease usually is made by detecting antibodies to Trypanosoma cruzi , the protozoan parasite that causes this illness. A highly sensitive and specific immunoblot assay developed by us showed a higher analytic sensitivity than the radioimmune precipitation as...

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Published inDiagnostic microbiology and infectious disease Vol. 67; no. 4; pp. 402 - 405
Main Authors Shah, Dinesh O, Chang, Chi-Deu, Cheng, Kevin Y, Salbilla, Vince A, Adya, Neeraj, Marchlewicz, Benedict A, Kirchhoff, Louis V
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.08.2010
Subjects
Analytic sensitivity
Antibodies, Protozoan - blood
Chagas disease
Chagas Disease - diagnosis
Humans
Immunoblot assay
Immunoblotting - methods
Infectious Disease
Internal Medicine
Parasitology - methods
Radioimmune precipitation assay
Radioimmunoassay - methods
RIPA
Sensitivity and Specificity
Trypanosoma cruzi
Trypanosoma cruzi - immunology
Chagas disease
Immunoblot assay
Radioimmune precipitation assay
Analytic sensitivity
RIPA
Trypanosoma cruzi
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Summary:Abstract The diagnosis of chronic Chagas disease usually is made by detecting antibodies to Trypanosoma cruzi , the protozoan parasite that causes this illness. A highly sensitive and specific immunoblot assay developed by us showed a higher analytic sensitivity than the radioimmune precipitation assay, which is used widely as a confirmatory test.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2010.03.013