Association of Serum Oxysterols with Cholesterol Metabolism Markers and Clinical Factors in Patients with Coronary Artery Disease: A Covariance Structure Analysis

• Published in: Nutrients Vol. 15; no. 13; p. 2997
• Main Authors: Akiyama, Yusuke, Katsuki, Shunsuke, Matoba, Tetsuya, Nakano, Yasuhiro, Takase, Susumu, Nakashiro, Soichi, Yamamoto, Mitsutaka, Mukai, Yasushi, Inoue, Shujiro, Oi, Keiji, Higo, Taiki, Takemoto, Masao, Suematsu, Nobuhiro, Eshima, Kenichi, Miyata, Kenji, Usui, Makoto, Sadamatsu, Kenji, Kadokami, Toshiaki, Hironaga, Kiyoshi, Ichi, Ikuyo, Todaka, Koji, Kishimoto, Junji, Tsutsui, Hiroyuki
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.06.2023; MDPI
• Subjects: absorption; Apolipoproteins; Biomarkers; blood serum; campesterol; Cardiac patients; Cardiovascular disease; Care and treatment; Cholesterol; cholesterol metabolism; Chromatography; Coronary Artery Disease; Coronary heart disease; Coronary vessels; covariance; Diabetes; High density lipoprotein; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; hyperlipidemia; Hypertension; Laboratories; Lipids; Metabolic disorders; Metabolic syndrome; Oxysterols; pathogenesis; Physiological aspects; physiological regulation; Phytosterols; Population; Software; Statins; Statistical analysis; Sterols; Vein & artery diseases; Japan; United States > US; cardiovascular disease; oxysterol; cholesterol metabolism
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu15132997

Oxysterols have been implicated in the pathogenesis of cardiovascular diseases. Serum levels of oxysterols could be positively correlated with cholesterol absorption and synthesis. However, physiological regulation of various serum oxysterols is largely unknown. The aim of this study was to investigate the relationship between clinical factors and cholesterol metabolism markers, and identify oxysterols associated with cholesterol absorption and synthesis in patients with coronary artery disease. Subjects (n = 207) who underwent coronary stenting between 2011 and 2013 were studied cross-sectionally. We measured lipid profiles including serum oxysterols. As for the serum biomarkers of cholesterol synthesis and absorption, oxysterol levels were positively correlated with campesterol and lathosterol. Covariance structure analysis revealed that dyslipidemia and statin usage had a positive correlation with “cholesterol absorption”. Statin usage also had a positive correlation with “cholesterol synthesis”. Several oxysterols associated with cholesterol absorption and/or synthesis. In conclusion, we elucidated the potential clinical factors that may affect cholesterol metabolism, and the associations between various oxysterols with cholesterol absorption and/or synthesis in patients with coronary artery disease.