Inflammation mechanism and anti-inflammatory therapy of dry eye

Dry eye is a widespread chronic inflammatory disease that causes fatigue, tingling, burning, and other symptoms. Dry eye is attributed to rheumatic diseases, diabetes, hormone disorders, and contact lenses, which activate inflammatory pathways: mitogen-activated protein kinases (MAPK) and nuclear fa...

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Published inFrontiers in medicine Vol. 11; p. 1307682
Main Authors Chu, Liyuan, Wang, Caiming, Zhou, Hongyan
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 14.02.2024
Subjects
dry eye
inflammation
mechanism
Medicine
review
therapy
dry eye
mechanism
inflammation
review
therapy
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Summary:Dry eye is a widespread chronic inflammatory disease that causes fatigue, tingling, burning, and other symptoms. Dry eye is attributed to rheumatic diseases, diabetes, hormone disorders, and contact lenses, which activate inflammatory pathways: mitogen-activated protein kinases (MAPK) and nuclear factor-B (NF-κB), promote macrophage inflammatory cell and T cell activation, and inflammation factors. Clinicians use a combination of anti-inflammatory drugs to manage different symptoms of dry eye; some of these anti-inflammatory drugs are being developed. This review introduces the dry eye inflammation mechanisms and the involved inflammatory factors. We also elucidate the anti-inflammatory drug mechanism and the detection limits.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Reviewed by: Hong Qi, Peking University Third Hospital, China
Edited by: Enzo Maria Vingolo, Sapienza University of Rome, Italy
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2024.1307682