Unveiling diagnostic and therapeutic strategies for cervical cancer: biomarker discovery through proteomics approaches and exploring the role of cervical cancer stem cells

Cervical cancer (CC) is a major global health problem and leading cause of cancer deaths among women worldwide. Early detection through screening programs has reduced mortality; however, screening compliance remains low. Identifying non-invasive biomarkers through proteomics for diagnosis and monito...

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Published inFrontiers in oncology Vol. 13; p. 1277772
Main Authors Jafari, Ameneh, Farahani, Masoumeh, Abdollahpour-Alitappeh, Meghdad, Manzari-Tavakoli, Asma, Yazdani, Mohsen, Rezaei-Tavirani, Mostafa
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 24.01.2024
Subjects
bioinformatics
biomarker
cancer stem cell
cervical cancer
diagnosis
Oncology
proteomics
diagnosis
cancer stem cell
proteomics
biomarker
cervical cancer
bioinformatics
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Summary:Cervical cancer (CC) is a major global health problem and leading cause of cancer deaths among women worldwide. Early detection through screening programs has reduced mortality; however, screening compliance remains low. Identifying non-invasive biomarkers through proteomics for diagnosis and monitoring response to treatment could improve patient outcomes. Here we review recent proteomics studies which have uncovered biomarkers and potential drug targets for CC. Additionally, we explore into the role of cervical cancer stem cells and their potential implications in driving CC progression and therapy resistance. Although challenges remain, proteomics has the potential to revolutionize the field of cervical cancer research and improve patient outcomes.
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Edited by: Marzieh Naseri, Tufts University, United States
Jorge Olmos, Ensenada Center for Scientific Research and Higher Education (CICESE), Mexico
Jeovanis Gil, Lund University, Sweden
Reviewed by: Xiaoyuan Huang, Huazhong University of Science and Technology, China
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2023.1277772