Characteristics and molecular mechanism of drug-tolerant cells in cancer: a review

Drug resistance in tumours has seriously hindered the therapeutic effect. Tumour drug resistance is divided into primary resistance and acquired resistance, and the recent study has found that a significant proportion of cancer cells can acquire stable drug resistance from scratch. This group of cel...

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Published inFrontiers in oncology Vol. 13; p. 1177466
Main Authors Liang, Xian-Wen, Liu, Bing, Chen, Jia-Cheng, Cao, Zhi, Chu, Feng-ran, Lin, Xiong, Wang, Sheng-Zhong, Wu, Jin-Cai
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 07.07.2023
Subjects
cancer
characteristics
drug tolerance
molecular mechanisms
Oncology
therapeutic strategies
characteristics
molecular mechanisms
cancer
drug tolerance
therapeutic strategies
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Summary:Drug resistance in tumours has seriously hindered the therapeutic effect. Tumour drug resistance is divided into primary resistance and acquired resistance, and the recent study has found that a significant proportion of cancer cells can acquire stable drug resistance from scratch. This group of cells first enters the drug tolerance state (DT state) under drug pressure, and gradually acquires stable drug resistance through adaptive mutations in this state. Although the specific mechanisms underlying the formation of drug tolerant cells (DTCs) remain unclear, various proteins and signalling pathways have been identified as being involved in the formation of DTCs. In the current review, we summarize the characteristics, molecular mechanisms and therapeutic strategies of DTCs in detail.
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Edited by: Mohamed Hassan, Institut National de la Santé et de la Recherche Médicale (INSERM), France
Reviewed by: Zhao Huang, Sichuan University, China; Naji Kharouf, Université de Strasbourg, France
These authors share first authorship
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2023.1177466