The Impact of Taurine on Obesity-Induced Diabetes Mellitus: Mechanisms Underlying Its Effect

• Published in: Endocrinology and metabolism (Seoul) Vol. 38; no. 5; pp. 482 - 492
• Main Authors: Ahmed, Kainat, Choi, Ha-Neul, Yim, Jung-Eun
• Format: Journal Article
• Language: English
• Published: Korean Endocrine Society 01.10.2023; 대한내분비학회
• Subjects: beta-cell dysfunction; diabetes complications; inflammation; obesity; Review; taurine; 내과학
• ISSN: 2093-596X; 2093-5978; 2093-5978
• DOI: 10.3803/EnM.2023.1776

This review explores the potential benefits of taurine in ameliorating the metabolic disorders of obesity and type 2 diabetes (T2D), highlighting the factors that bridge these associations. Relevant articles and studies were reviewed to conduct a comprehensive analysis of the relationship between obesity and the development of T2D and the effect of taurine on those conditions. The loss of normal β-cell function and development of T2D are associated with obesity-derived insulin resistance. The occurrence of diabetes has been linked to the low bioavailability of taurine, which plays critical roles in normal β-cell function, anti-oxidation, and anti-inflammation. The relationships among obesity, insulin resistance, β-cell dysfunction, and T2D are complex and intertwined. Taurine may play a role in ameliorating these metabolic disorders through different pathways, but further research is needed to fully understand its effects and potential as a therapeutic intervention.