Gastric mixed neuroendocrine non-neuroendocrine neoplasms

The uncommon tumour known as gastric mixed neuroendocrine-non-neuroendocrine neoplasms (G-MiNENs) is made up of parts of neuroendocrine carcinoma and adenocarcinoma. The biological and clinical features are different from those of gastric adenocarcinoma. Their pathophysiology, diagnostic standards,...

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Published inFrontiers in oncology Vol. 14; p. 1335760
Main Authors Liu, Li, Li, Qian, Liu, Wenxuan, Qiu, Zhendong, Wu, Zhongkai, Yu, Danli, Deng, Wenhong
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 08.04.2024
Subjects
gastric cancer
MINENs
neuroendocrine tumours
Oncology
prognosis
treatment
treatment
neuroendocrine tumours
gastric cancer
prognosis
MINENs
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Summary:The uncommon tumour known as gastric mixed neuroendocrine-non-neuroendocrine neoplasms (G-MiNENs) is made up of parts of neuroendocrine carcinoma and adenocarcinoma. The biological and clinical features are different from those of gastric adenocarcinoma. Their pathophysiology, diagnostic standards, and clinical behaviour have all been the subject of lengthy debates, and their nomenclature has undergone multiple changes. Its emergence has created new challenges in the classification and diagnosis of gastric tumours. This review will update information on the topic, covering molecular aspects, diagnostic criteria, treatment, and prognostic factor discovery. It will also provide a historical context that will aid in understanding the evolution of the idea and nomenclature of mixed gastric tumours. Additionally, it will provide the reader a thorough understanding of this difficult topic of cancer that is applicable to real-world situations.
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Eleonora Lauricella, Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari, Italy
Edited by: Mauro Cives, University of Bari Aldo Moro, Italy
These authors have contributed equally to this work
Reviewed by: Faidon Marios Laskaratos, St. Mark’s Hospital, United Kingdom
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2024.1335760