The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders

Emerging evidence indicates that the gut microbiota play a crucial role in the bidirectional communication between the gut and the brain suggesting that the gut microbes may shape neural development, modulate neurotransmission and affect behavior, and thereby contribute to the pathogenesis and/or pr...

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Published inPharmacological research Vol. 172; p. 105840
Main Authors Socała, Katarzyna, Doboszewska, Urszula, Szopa, Aleksandra, Serefko, Anna, Włodarczyk, Marcin, Zielińska, Anna, Poleszak, Ewa, Fichna, Jakub, Wlaź, Piotr
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.10.2021
Subjects
Animals
Brain-Gut Axis
Fecal microbiota transplantation
Gastrointestinal Microbiome
Humans
Mental Disorders - microbiology
Microbiota-gut-brain axis
Nervous System Diseases - microbiology
Neurological diseases
Neuropsychiatric disorders
Probiotics
NTG
Microbiota-gut-brain axis
BBB
ANS
Fecal microbiota transplantation
CUMS
CNS
ENS
LPS
ASD
NADH
ECs
FDR
B-GOS
IBS
TLR
GF
GI
BDNF
MS
FMT
HAMA
Neurological diseases
HAMD
Probiotics
Neuropsychiatric disorders
PF
TJ
EPA
HPA
SCFAs
DHA
PUFAs
ASDs
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Summary:Emerging evidence indicates that the gut microbiota play a crucial role in the bidirectional communication between the gut and the brain suggesting that the gut microbes may shape neural development, modulate neurotransmission and affect behavior, and thereby contribute to the pathogenesis and/or progression of many neurodevelopmental, neuropsychiatric, and neurological conditions. This review summarizes recent data on the role of microbiota-gut-brain axis in the pathophysiology of neuropsychiatric and neurological disorders including depression, anxiety, schizophrenia, autism spectrum disorders, Parkinson’s disease, migraine, and epilepsy. Also, the involvement of microbiota in gut disorders co-existing with neuropsychiatric conditions is highlighted. We discuss data from both in vivo preclinical experiments and clinical reports including: (1) studies in germ-free animals, (2) studies exploring the gut microbiota composition in animal models of diseases or in humans, (3) studies evaluating the effects of probiotic, prebiotic or antibiotic treatment as well as (4) the effects of fecal microbiota transplantation. [Display omitted]
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ISSN:1043-6618
1096-1186
1096-1186
DOI:10.1016/j.phrs.2021.105840