A 20-cm cut umbilical cord milking may not benefit the preterm infants < 30 week's gestation: A randomized clinical trial

• Published in: Journal of the Formosan Medical Association Vol. 121; no. 5; pp. 912 - 919
• Main Authors: Shen, Shang-Po, Chen, Chih-Hao, Chang, Hung-Yang, Hsu, Chyong-Hsin, Lin, Chia-Ying, Jim, Wai-Tim, Chang, Jui-Hsing
• Format: Journal Article
• Language: English
• Published: Singapore Elsevier B.V 01.05.2022; Elsevier
• Subjects: Female; Humans; Infant; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Placental transfusion; Pregnancy; Premature Birth; Preterm; Randomized controlled trial; Umbilical Cord; Umbilical Cord Clamping; Placental transfusion; Umbilical cord; Randomized controlled trial; Preterm
• ISSN: 0929-6646; 1876-0821
• DOI: 10.1016/j.jfma.2021.09.013

To evaluate whether a shorter length (20 cm) of C-UCM has potential benefits, compared to immediate cord clamping (ICC), in very preterm babies. Inborn preterm infants less than 30 weeks of gestational age (GA) were randomly assigned to the 20-cm C-UMC and ICC groups. The primary outcome was the need for packed red blood cell (pRBC) transfusion before the 21st day of life. The secondary outcomes were short- and long-term outcomes related to premature birth. Seventy-six neonates were randomized to the two groups. GA were 27.2 ± 1.8 and 27.5 ± 1.7 weeks (p = 0.389) and birth weights were 987 ± 269 and 1023 ± 313 g (p = 0.601) in the 20-cm C-UCM and ICC groups, respectively. There was no significant difference between the groups in terms of the need for pRBC transfusion before the 21st day of life (59.4% versus 71.8%, adjusted odds ratio [aOR] 0.311, 95% confidence interval [CI] 0.090–1.079). An increased prevalence of late-onset sepsis was observed in the 20-cm C-UCM group compared to the ICC group (21.6% versus 5.1%, aOR 5.434, 95% CI 1.033–23.580). The mortality rates were 13.5% and 2.6% in the 20-cm C-UCM and ICC groups, respectively (aOR 5.339, 95% CI 0.563–50.626). The neurodevelopmental outcomes at 2 years of corrected age between the groups were also not statistically significant. A 20-cm C-UCM showed no effect on reducing the incidence of pRBC transfusion in preterm babies with GA less than 30 weeks compared with ICC in this small-scale randomized controlled trial.