Contrasting roles for dopamine D1 and D2 receptor subtypes in the dorsomedial striatum but not the nucleus accumbens core during behavioral inhibition in the stop-signal task in rats

• Published in: The Journal of neuroscience Vol. 31; no. 20; pp. 7349 - 7356
• Main Authors: Eagle, Dawn M, Wong, Jacky C K, Allan, Michelle E, Mar, Adam C, Theobald, David E, Robbins, Trevor W
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 18.05.2011
• Subjects: Animals; Behavior, Animal - drug effects; Behavior, Animal - physiology; Benzazepines - pharmacology; Corpus Striatum - drug effects; Corpus Striatum - physiology; Dopamine D2 Receptor Antagonists; Inhibition, Psychological; Male; Nucleus Accumbens - drug effects; Nucleus Accumbens - physiology; Psychomotor Performance - drug effects; Psychomotor Performance - physiology; Rats; Reaction Time - drug effects; Reaction Time - physiology; Receptors, Dopamine D1 - antagonists & inhibitors; Receptors, Dopamine D1 - physiology; Receptors, Dopamine D2 - physiology; Sulpiride - pharmacology
• ISSN: 0270-6474; 1529-2401; 1529-2401
• DOI: 10.1523/JNEUROSCI.6182-10.2011

Dopamine and dopamine-receptor function are often implicated in behavioral inhibition, and deficiencies within behavioral inhibition processes linked to attention deficit/hyperactivity disorder (ADHD), schizophrenia, obsessive-compulsive disorder, and drug addiction. In the stop-signal task, which measures the speed of the process of inhibition [stop-signal reaction time (SSRT)], psychostimulant-related improvement of SSRT in ADHD is linked with dopamine function. However, the precise nature of dopaminergic control over SSRT remains unclear. This study examined region- and receptor-specific modulation of SSRT in the rat using direct infusions of the dopamine D1 receptor (DRD1) antagonist SCH 23390 or dopamine D2 receptor (DRD2) antagonist sulpiride into the dorsomedial striatum (DMStr) or nucleus accumbens core (NAcbC). DRD1 and DRD2 antagonists had contrasting effects on SSRT that were specific to the DMStr. SCH 23390 decreased SSRT with little effect on the go response. Conversely, sulpiride increased SSRT but also increased go-trial reaction time and reduced trial completion at the highest doses. These results suggest that DRD1 and DRD2 function within the DMStr, but not the NAcbC, may act to balance behavioral inhibition in a manner that is independent of behavioral activation.