Male reproductive health in cystic fibrosis

• Published in: Journal of cystic fibrosis Vol. 18; pp. S105 - S110
• Main Authors: Yoon, John C., Casella, Julio Leey, Litvin, Marina, Dobs, Adrian S.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2019
• Subjects: Cystic fibrosis; Cystic Fibrosis - complications; Humans; Hypogonadism; Hypogonadism - diagnosis; Hypogonadism - etiology; Hypogonadism - therapy; Infertility; Infertility, Male - diagnosis; Infertility, Male - etiology; Infertility, Male - physiopathology; Infertility, Male - therapy; Male; Obstructive azoospermia; Testosterone - deficiency; Cystic fibrosis; Obstructive azoospermia; Infertility; Testosterone deficiency; Hypogonadism
• ISSN: 1569-1993; 1873-5010
• DOI: 10.1016/j.jcf.2019.08.007

The impact of cystic fibrosis (CF) on male reproductive health is profound. The vast majority of men with CF are infertile due to obstructive azoospermia. Multiple factors associated with CF contribute to an increased prevalence of testosterone deficiency, which adversely affects muscle mass, bone density, and quality of life. This article reviews the pathophysiology, diagnosis, and management of infertility and testosterone deficiency that occur in men with CF. With improving survival of CF patients, these topics are becoming more significant in their clinical care. •Infertility affects nearly all men with CF and is from anatomical obstruction.•They still produce sperm and can potentially father children by harvesting sperm.•Male hypogonadism is seen in CF and is diagnosed based on morning serum testosterone.•Measurement of FSH and LH can distinguish between primary and secondary hypogonadism.•A variety of different testosterone preparations are available for replacement.