Light-controlled active release of photocaged ciprofloxacin for lipopolysaccharide-targeted drug delivery using dendrimer conjugates

• Published in: Chemical communications (Cambridge, England) Vol. 52; no. 68; pp. 1357 - 136
• Main Authors: Wong, Pamela T, Tang, Shengzhuang, Mukherjee, Jhindan, Tang, Kenny, Gam, Kristina, Isham, Danielle, Murat, Claire, Sun, Rachel, Baker, James R, Choi, Seok Ki
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 16.08.2016
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - radiation effects; Bacteria; chemical reactions; Chemistry; Chemistry, Multidisciplinary; ciprofloxacin; Ciprofloxacin - chemistry; Ciprofloxacin - pharmacology; Ciprofloxacin - radiation effects; Conjugates; Dendrimers; Dendrimers - chemical synthesis; Dendrimers - chemistry; Drug Delivery Systems; drugs; Escherichia coli - drug effects; Escherichia coli - metabolism; Gram-negative bacteria; Gram-Negative Bacteria - drug effects; Gram-Negative Bacteria - metabolism; Ligands; Lipopolysaccharides - metabolism; Nanoconjugates - chemistry; Nanostructure; photochemistry; Physical Sciences; Polyamines - chemical synthesis; Polyamines - chemistry; Polymyxin B - chemistry; Science & Technology; Ultraviolet Rays; ANTIBODIES; METHOTREXATE; NANOPARTICLES; NANOPLATFORM; PRESENTING VANCOMYCIN
• ISSN: 1359-7345; 1364-548X; 1364-548X
• DOI: 10.1039/c6cc05179k

We report an active delivery mechanism targeted specifically to Gram(−) bacteria based on the photochemical release of photocaged ciprofloxacin carried by a cell wall-targeted dendrimer nanoconjugate. We report a light-controlled release mechanism for photocaged ciprofloxacin nanoconjugate. Validation of this bacteria-targeted strategy adds a novel modality to light-based therapies for wound treatments.