Implementation of the surface gradiometer receive coils for the improved detection limit and sensitivity in the single-sided MPI scanner

• Published in: Physics in medicine & biology Vol. 67; no. 24; pp. 245009 - 245020
• Main Authors: McDonough, C, Pagan, J, Tonyushkin, A
• Format: Journal Article
• Language: English
• Published: England IOP Publishing 09.12.2022
• Subjects: Diagnostic Imaging - methods; field free line; Humans; Limit of Detection; Magnetic Iron Oxide Nanoparticles; magnetic particle imaging; Magnetite Nanoparticles; nanoparticles; recieve coils; single-sided; field free line; nanoparticles; recieve coils; single-sided; magnetic particle imaging
• ISSN: 0031-9155; 1361-6560; 1361-6560
• DOI: 10.1088/1361-6560/aca5ec

Objective. Magnetic Particle Imaging (MPI) promises to enhance diagnostic capabilities of the existing clinical imaging modalities. Traditional MPI scanners utilize cylindrical bore geometry that prevents scaling up the MPI to accommodate full human subject. Single-sided geometry, on the other hand, has all the hardware located on one side providing an unrestricted imaging volume. Approach. Our single-sided MPI device utilizes a field-free line topology with a single drive coil and a surface receive coil, which is used to detect the nanoparticles. Unlike closed bore systems, single-sided devices cannot adapt well established solenoid gradiometer receive coil, which result in impinging potential sensitivity gain. Main results. In this work we study multiple receive coil configurations with compensation for the purpose of removing feedthrough, whilst preserving the superparamagnetic iron oxide nanoparticle signal. Moreover, we present a compensated surface receive coil design that provides highest sensitivity in the single-sided geometry and demonstrate a new detection limit in a single-sided scanner of 100 ng of iron. In addition, we demonstrate 1D imaging of a sample without use of receive filter recovering signal at fundamental harmonic. Significance. These advancements in the receive chain are crucial for developing a practical MPI scanner with a single-sided geometry.